Virology Unit, Pisa University Hospital, Pisa, Italy.
Clin Microbiol Infect. 2012 Feb;18(2):184-8. doi: 10.1111/j.1469-0691.2011.03580.x. Epub 2011 Jun 14.
The human pathogen xenotropic murine leukaemia virus-related virus (XMRV) has been tentatively associated with prostate cancer and chronic fatigue syndrome. Unfortunately, subsequent studies failed to identify the virus in various clinical settings. To determine whether XMRV circulates in humans and the relationship with its host, we searched for the virus in 124 human immunodeficiency virus-infected patients who might have been exposed to XMRV, might be prone to infection as a result of progressive immunodeficiency, and had not yet been treated with antiretroviral drugs. Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV.
人病原体嗜性鼠白血病病毒相关病毒（XMRV）曾被推测与前列腺癌和慢性疲劳综合征有关。不幸的是，随后的研究未能在各种临床环境中发现该病毒。为了确定 XMRV 是否在人类中传播及其与宿主的关系，我们在 124 名可能接触过 XMRV 的感染人类免疫缺陷病毒的患者中搜索了该病毒，这些患者可能由于进行性免疫缺陷而容易感染，并且尚未接受抗逆转录病毒药物治疗。使用基于 XMRV gag 基因设计的巢式 PCR 和一步 TaqMan 实时 PCR，我们均未发现任何阳性样本。这些发现增加了对 XMRV 的怀疑。
