• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种细胞因子与单纯疱疹病毒1型反式激活因子Vmw65结合，是Vmw65与Oct-1形成依赖于Vmw65的蛋白质-DNA复合物所必需的。

A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.

作者信息

Xiao P, Capone J P

机构信息

Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.

出版信息

Mol Cell Biol. 1990 Sep;10(9):4974-7. doi: 10.1128/mcb.10.9.4974-4977.1990.

DOI:10.1128/mcb.10.9.4974-4977.1990
PMID:2167442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361125/
Abstract

The herpes simplex virus transactivator Vmw65 assembles into a multicomponent protein-DNA complex along with the octamer binding protein Oct-1. Using affinity chromatography on columns conjugated with purified Vmw65 fusion protein expressed in Escherichia coli, we demonstrate that a cellular factor, distinct from Oct-1, binds to Vmw65 in the absence of target DNA and is necessary for Vmw65-mediated complex assembly with Oct-1.

摘要

单纯疱疹病毒反式激活因子Vmw65与八聚体结合蛋白Oct-1一起组装成多组分蛋白质-DNA复合物。通过在与大肠杆菌中表达的纯化Vmw65融合蛋白偶联的柱上进行亲和层析，我们证明了一种不同于Oct-1的细胞因子在没有靶DNA的情况下与Vmw65结合，并且是Vmw65介导的与Oct-1的复合物组装所必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/08e84a2770bf/molcellb00045-0548-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/64c9a89edab5/molcellb00045-0547-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/e3237b963031/molcellb00045-0548-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/08e84a2770bf/molcellb00045-0548-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/64c9a89edab5/molcellb00045-0547-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/e3237b963031/molcellb00045-0548-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ac/361125/08e84a2770bf/molcellb00045-0548-b.jpg

相似文献

1
A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.一种细胞因子与单纯疱疹病毒1型反式激活因子Vmw65结合，是Vmw65与Oct-1形成依赖于Vmw65的蛋白质-DNA复合物所必需的。
Mol Cell Biol. 1990 Sep;10(9):4974-7. doi: 10.1128/mcb.10.9.4974-4977.1990.
2
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65.一种异常的细胞因子增强了Oct-1与Vmw65之间的蛋白质-DNA复合物组装。
J Biol Chem. 1993 Jan 15;268(2):1272-8.
3
Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex.一种在多组分转录复合体组装过程中与Oct-1发生功能性相互作用的细胞因子的特性分析。
Nucleic Acids Res. 1990 Dec 11;18(23):6871-80. doi: 10.1093/nar/18.23.6871.
4
Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.单纯疱疹病毒1型反式激活因子Vmw65与细胞八聚体结合蛋白及靶TAATGARAT序列相互作用的结构要求。
J Virol. 1990 Jun;64(6):2716-24. doi: 10.1128/JVI.64.6.2716-2724.1990.
5
Interference with the assembly of a virus-host transcription complex by peptide competition.通过肽竞争干扰病毒-宿主转录复合物的组装。
Nature. 1990 Mar 15;344(6263):257-9. doi: 10.1038/344257a0.
6
The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.八聚体结合蛋白与单纯疱疹病毒α TIF调节蛋白形成多蛋白-DNA复合物。
EMBO J. 1989 Dec 20;8(13):4229-38. doi: 10.1002/j.1460-2075.1989.tb08608.x.
7
Positive and negative regulation at the herpes simplex virus ICP4 and ICP0 TAATGARAT motifs.单纯疱疹病毒ICP4和ICP0 TAATGARAT基序的正负调控
Virology. 1995 Feb 20;207(1):107-16. doi: 10.1006/viro.1995.1056.
8
Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.Oct-1 POU亚结构域与特定DNA序列及单纯疱疹病毒α反式激活蛋白的相互作用。
Genes Dev. 1990 Dec;4(12B):2383-96. doi: 10.1101/gad.4.12b.2383.
9
The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation.B细胞共激活因子Bob1与Oct-1/Oct-2因子形成依赖于DNA序列的复合物，从而导致启动子的差异性激活。
EMBO J. 1996 Jun 3;15(11):2781-90.
10
Herpes simplex virus Vmw65-octamer binding protein interaction: a paradigm for combinatorial control of transcription.单纯疱疹病毒Vmw65-八聚体结合蛋白相互作用：转录组合控制的范例
Virology. 1989 Dec;173(2):363-7. doi: 10.1016/0042-6822(89)90548-5.

引用本文的文献

1
HCFC2 is needed for IRF1- and IRF2-dependent transcription and for survival during viral infections.HCFC2是IRF1和IRF2依赖性转录以及病毒感染期间存活所必需的。
J Exp Med. 2017 Nov 6;214(11):3263-3277. doi: 10.1084/jem.20161630. Epub 2017 Oct 2.
2
An Essential Viral Transcription Activator Modulates Chromatin Dynamics.一种重要的病毒转录激活因子调节染色质动力学。
PLoS Pathog. 2016 Aug 30;12(8):e1005842. doi: 10.1371/journal.ppat.1005842. eCollection 2016 Aug.
3
Nuclear Translocation Sequence and Region in Autographa californica Multiple Nucleopolyhedrovirus ME53 That Are Important for Optimal Baculovirus Production.

本文引用的文献

1
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. doi: 10.1093/nar/11.5.1475.
2
Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes.在单纯疱疹病毒1型α基因调控域内，将定义基础表达的序列与赋予α基因识别能力的序列分开。
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4065-9. doi: 10.1073/pnas.81.13.4065.
3
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes.
苜蓿银纹夜蛾多核型多角体病毒ME53中对杆状病毒最佳生产至关重要的核转位序列和区域。
J Virol. 2016 Mar 28;90(8):3953-3965. doi: 10.1128/JVI.03115-15. Print 2016 Apr.
4
The number of alphaherpesvirus particles infecting axons and the axonal protein repertoire determines the outcome of neuronal infection.感染轴突的α疱疹病毒颗粒数量和轴突蛋白组成决定了神经元感染的结果。
mBio. 2015 Mar 24;6(2):e00276-15. doi: 10.1128/mBio.00276-15.
5
The making of a sweet modification: structure and function of O-GlcNAc transferase.一种糖基化修饰的形成：O-连接的N-乙酰葡糖胺转移酶的结构与功能
J Biol Chem. 2014 Dec 12;289(50):34424-32. doi: 10.1074/jbc.R114.604405. Epub 2014 Oct 21.
6
Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes.核纤层在稳定核结合和疱疹病毒即刻早期基因上的转录激活复合物组装中的作用。
mBio. 2012 Jan 17;3(1). doi: 10.1128/mBio.00300-11. Print 2012.
7
Host cell protein C9orf69 promotes viral proliferation via interaction with HSV-1 UL25 protein.宿主细胞蛋白 C9orf69 通过与 HSV-1 UL25 蛋白相互作用促进病毒增殖。
Virol Sin. 2011 Jun;26(3):171-80. doi: 10.1007/s12250-011-3179-8. Epub 2011 Jun 12.
8
Tegument protein control of latent herpesvirus establishment and animation.被膜蛋白对潜伏性疱疹病毒建立及激活的控制
Herpesviridae. 2011 Feb 8;2(1):3. doi: 10.1186/2042-4280-2-3.
9
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.通过PGC-1家族调控网络对线粒体生物发生的代谢控制。
Biochim Biophys Acta. 2011 Jul;1813(7):1269-78. doi: 10.1016/j.bbamcr.2010.09.019. Epub 2010 Oct 13.
10
Sequence and function of canine herpesvirus alpha-transinducing factor and its interaction with an immediate early promoter.犬疱疹病毒α-反式诱导因子的序列与功能及其与一个立即早期启动子的相互作用
Virus Genes. 2006 Dec;33(3):299-307. doi: 10.1007/s11262-006-0069-5.
负责诱导α基因的单纯疱疹病毒粒子相关因子的特性分析
J Virol. 1983 May;46(2):371-7. doi: 10.1128/JVI.46.2.371-377.1983.
4
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.单纯疱疹病毒α基因4、0和27启动子调控序列的结构特征，这些序列赋予嵌合胸苷激酶基因α调控作用。
J Virol. 1982 Dec;44(3):939-49. doi: 10.1128/JVI.44.3.939-949.1982.
5
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.单纯疱疹病毒α基因的调控：由胸苷激酶与α基因启动子融合产生的嵌合基因的表达。
Cell. 1981 May;24(2):555-65. doi: 10.1016/0092-8674(81)90346-9.
6
In vitro transcription: whole-cell extract.体外转录：全细胞提取物
Methods Enzymol. 1983;101:568-82. doi: 10.1016/0076-6879(83)01038-1.
7
The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.单纯疱疹病毒1型的65,000道尔顿DNA结合及病毒体反式诱导蛋白
J Virol. 1987 Aug;61(8):2428-37. doi: 10.1128/JVI.61.8.2428-2437.1987.
8
Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes.宿主细胞蛋白与病毒体介导的单纯疱疹病毒1型α基因诱导所需的顺式作用位点结合。
Proc Natl Acad Sci U S A. 1987 Jan;84(1):71-5. doi: 10.1073/pnas.84.1.71.
9
Analysis of DNA sequences which regulate the transcription of herpes simplex virus immediate early gene 3: DNA sequences required for enhancer-like activity and response to trans-activation by a virion polypeptide.单纯疱疹病毒立即早期基因3转录调控的DNA序列分析：增强子样活性及对病毒体多肽反式激活反应所需的DNA序列
Nucleic Acids Res. 1986 Jan 24;14(2):929-43. doi: 10.1093/nar/14.2.929.
10
DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters.单纯疱疹病毒1型基因的DNA序列，其产物负责立即早期启动子的转录激活。
Nucleic Acids Res. 1985 Nov 11;13(21):7865-79. doi: 10.1093/nar/13.21.7865.