Yale-Griffin Prevention Research Center, Derby, CT 06418, USA.
Am J Public Health. 2011 Aug;101(8):e17-27. doi: 10.2105/AJPH.2010.300104. Epub 2011 Jun 16.
Methods for translating the findings of controlled trials, such as the Diabetes Prevention Program, into real-world community application have not been clearly defined. A standardized research methodology for making and evaluating such a transition is needed. We introduce the multisite translational community trial (mTCT) as the research analog to the multisite randomized controlled trial. The mTCT is adapted to incorporate the principles and practices of community-based participatory research and the increased relevance and generalizability gained from diverse community settings. The mTCT is a tool designed to bridge the gap between what a clinical trial demonstrates can work in principle and what is needed to make it workable and effective in real-world settings. Its utility could be put to the test, in particular with practice-based research networks such as the Prevention Research Centers.
目前，尚未明确界定如何将控制试验（如糖尿病预防计划）的研究成果转化为实际社区应用。需要一种标准化的研究方法来进行这种转变，并对其进行评估。我们引入了多地点转化社区试验（mTCT），作为多地点随机对照试验的研究模拟。mTCT 经过调整，纳入了基于社区的参与式研究的原则和实践，以及从不同社区环境中获得的相关性和普遍性的提高。mTCT 是一种旨在弥合临床试验所证明的可行原则与在实际环境中使其可行和有效的实际需求之间差距的工具。它的实用性可以通过实践研究网络（如预防研究中心）进行检验。
