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阿米卡星耐药基因aphA6在不动杆菌属中的传播

Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp.

作者信息

Lambert T, Gerbaud G, Bouvet P, Vieu J F, Courvalin P

机构信息

Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

出版信息

Antimicrob Agents Chemother. 1990 Jun;34(6):1244-8. doi: 10.1128/AAC.34.6.1244.

DOI:10.1128/AAC.34.6.1244
PMID:2168146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171792/
Abstract

The distribution of the aphA6 gene, encoding a 3'-aminoglycoside phosphotransferase type VI, was studied by dot blot hybridization with 115 amikacin-resistant Acinetobacter strains from various geographical areas. Nucleotide sequences related to aphA6 were found in 109 strains belonging to seven species. As inferred from results of Southern hybridization, dissemination of amikacin resistance in Acinetobacter spp. is due to a gene rather than a strain or plasmid epidemic.

摘要

通过斑点杂交法，利用来自不同地理区域的115株耐阿米卡星不动杆菌菌株，研究了编码VI型3'-氨基糖苷磷酸转移酶的aphA6基因的分布情况。在属于七个物种的109株菌株中发现了与aphA6相关的核苷酸序列。从Southern杂交结果推断，不动杆菌属中阿米卡星耐药性的传播是由于一个基因，而非菌株或质粒的流行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/336a/171792/a3a5ea25ef76/aac00062-0347-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/336a/171792/686628f99160/aac00062-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/336a/171792/a3a5ea25ef76/aac00062-0347-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/336a/171792/686628f99160/aac00062-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/336a/171792/a3a5ea25ef76/aac00062-0347-b.jpg

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