Sheehan David V, Chokka Pratap R, Granger Renee E, Walton Richard J, Raskin Joel, Sagman Doron
College of Medicine, University of South Florida, Tampa, FL, USA.
Hum Psychopharmacol. 2011 Apr;26(3):242-51. doi: 10.1002/hup.1199.
This post hoc analysis of a multicenter, single-arm, open-label trial (the Attributes of Response in Depressed Patients Switched to Treatment with Duloxetine [ARDENT] study) assessed the relationship between functional improvement in the Sheehan Disability Scale (SDS) and clinical outcomes of mood, pain, and anxiety over 8 weeks after switching treatment to duloxetine in patients with major depressive disorder.
Analyses included all 195 patients who completed the study. Pearson's correlation and multivariate regression analyses were used to evaluate the relationship between change from baseline in SDS total score and 17-item Hamilton Rating Scale for Depression (HAMD(17)) Maier score (mood), Brief Pain Inventory-Short Form average pain score (pain), and Hamilton Anxiety Rating Scale total score (anxiety) at week 8.
At week 8, change in SDS total score was positively correlated with change in mood (r = 0.49), anxiety (r = 0.44), and pain (r = 0.40). Multivariate linear regression coefficients for mood and pain were estimated at 1.21 (standard error [SE] = 0.184) and 1.16 (SE = 0.180), respectively (both p < 0.0001) compared with 0.02 (SE = 0.097; p = 0.82) for anxiety. Overall, 43% of patients achieved both HAMD(17) and SDS total remission.
Functional improvement at 8 weeks was positively correlated with mood, pain, and anxiety in patients with major depressive disorder switched to duloxetine. Change in mood and pain exerted a relatively stronger joint effect on functioning than did anxiety in this patient population. Copyright © 2011 John Wiley & Sons, Ltd.
本对一项多中心、单臂、开放标签试验（转向度洛西汀治疗的抑郁症患者的反应特征[ARDENT]研究）的事后分析，评估了在重度抑郁症患者转向度洛西汀治疗8周后，希恩残疾量表（SDS）功能改善与情绪、疼痛和焦虑临床结局之间的关系。
分析纳入了所有195名完成该研究的患者。采用Pearson相关性分析和多元回归分析，以评估SDS总分相对于基线的变化与第8周时17项汉密尔顿抑郁量表（HAMD(17)）迈尔评分（情绪）、简明疼痛量表简表平均疼痛评分（疼痛）和汉密尔顿焦虑量表总分（焦虑）之间的关系。
在第8周时，SDS总分的变化与情绪变化（r = 0.49）、焦虑变化（r = 0.44）和疼痛变化（r = 0.40）呈正相关。情绪和疼痛的多元线性回归系数分别估计为1.21（标准误[SE]=0.184）和1.16（SE = 0.180）（均p < 0.0001），而焦虑的回归系数为0.02（SE = 0.097；p = 0.82）。总体而言，43%的患者实现了HAMD(17)和SDS总分完全缓解。
转向度洛西汀治疗的重度抑郁症患者在8周时的功能改善与情绪、疼痛和焦虑呈正相关。在该患者群体中，情绪和疼痛变化对功能的联合影响相对强于焦虑。版权所有© 2011约翰威立父子有限公司。
