结核分枝杆菌的菌株多样性、上位性和耐药性进化。
Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis.
机构信息
Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland University of Basel, Basel, Switzerland.
出版信息
Clin Microbiol Infect. 2011 Jun;17(6):815-20. doi: 10.1111/j.1469-0691.2011.03556.x.
Abstract
Mycobacterium tuberculosis harbours little DNA sequence diversity compared with other bacteria. However, there is mounting evidence that strain-to-strain variation in this organism has been underestimated. We review our current understanding of the genetic diversity among M. tuberculosis clinical strains and discuss the relevance of this diversity for the ongoing global epidemics of drug-resistant tuberculosis. Based on findings in other bacteria, we propose that epistatic interactions between pre-existing differences in strain genetic background, acquired drug-resistance-conferring mutations and compensatory changes could play a role in the emergence and spread of drug-resistant M. tuberculosis.
摘要
与其他细菌相比，结核分枝杆菌的 DNA 序列多样性很小。然而，越来越多的证据表明，该生物体的菌株间变异被低估了。我们回顾了目前对结核分枝杆菌临床菌株遗传多样性的认识，并讨论了这种多样性对当前全球耐药性结核病流行的意义。基于其他细菌的研究结果，我们提出，菌株遗传背景、获得性耐药性赋予突变和补偿性变化之间的上位性相互作用可能在耐药结核分枝杆菌的出现和传播中发挥作用。
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