Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan.
Cancer Lett. 2011 Oct 1;309(1):46-53. doi: 10.1016/j.canlet.2011.05.014. Epub 2011 Jun 17.
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.
白藜芦醇（3,5,4'-三羟基反式二苯乙烯），一种存在于葡萄和其他植物中的植物抗毒素，在人类动脉粥样硬化和致癌作用中发挥保护作用。我们研究了白藜芦醇对间变大细胞淋巴瘤（ALCL）细胞系 SR-786 的作用。白藜芦醇抑制生长并诱导细胞分化，表现为形态变化和 T 细胞分化标志物 CD2、CD3 和 CD8 的表达升高。白藜芦醇还触发细胞凋亡，表现为形态学观察、DNA 片段化和细胞周期分析。此外，白藜芦醇处理后死亡受体 Fas/CD95 的表面表达增加。我们的数据表明，白藜芦醇可能对 ALCL 具有潜在的治疗价值。
