Department of BIN Fusion Technology, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.
Biosens Bioelectron. 2011 Aug 15;26(12):4637-48. doi: 10.1016/j.bios.2011.05.039. Epub 2011 Jun 2.
A detailed overview towards the advancement of graphene based biosensors has been reviewed. The large surface area and excellent electrical conductivity of graphene allow it to act as an "electron wire" between the redox centers of an enzyme or protein and an electrode's surface. Rapid electron transfer facilitates accurate and selective detection of biomolecules. This review discusses the application of graphene for the detection of glucose, Cyt-c, NADH, Hb, cholesterol, AA, UA, DA, and H(2)O(2). GO and RGO have been used for the fabrication of heavy metal ion sensors, gas sensors, and DNA sensors. Graphene based FETs have also been discussed in details. In all these cases, the biosensors performed well with low working potentials, high sensitivities, low detection limits, and long-term stabilities.
已经对基于石墨烯的生物传感器的进展进行了详细的综述。石墨烯的大表面积和优异的导电性使其能够充当酶或蛋白质的氧化还原中心与电极表面之间的“电子导线”。快速的电子转移促进了生物分子的准确和选择性检测。本综述讨论了石墨烯在检测葡萄糖、Cyt-c、NADH、Hb、胆固醇、AA、UA、DA 和 H(2)O(2)中的应用。GO 和 RGO 已被用于制造重金属离子传感器、气体传感器和 DNA 传感器。基于石墨烯的 FET 也已被详细讨论。在所有这些情况下，生物传感器都表现出良好的性能，具有低工作电位、高灵敏度、低检测限和长期稳定性。
