Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Professor CR Rao Road, Gachibowli, Hyderabad 500 046, India.
J Bacteriol. 2011 Aug;193(16):4272-3. doi: 10.1128/JB.05413-11. Epub 2011 Jun 17.
Uropathogenic Escherichia coli (UPEC) causes serious infections in people at risk and has a significant environmental prevalence due to contamination by human and animal excreta. In developing countries, UPEC assumes importance in certain dwellings because of poor community/personal hygiene and exposure to contaminated water or soil. We report the complete genome sequence of E. coli strain NA114 from India, a UPEC strain with a multidrug resistance phenotype and the capacity to produce extended-spectrum beta-lactamase. The genome sequence and comparative genomics emanating from it will be significant in under-standing the genetic makeup of diverse UPEC strains and in boosting the development of new diagnostics/vaccines.
尿路致病性大肠杆菌（UPEC）可导致高危人群发生严重感染，由于人类和动物排泄物的污染，其在环境中的存在也非常普遍。在发展中国家，由于社区/个人卫生条件差以及接触污染的水或土壤，UPEC 在某些住宅中变得非常重要。我们报告了来自印度的大肠杆菌 NA114 菌株的完整基因组序列，该菌株是一种具有多药耐药表型和产生扩展谱β-内酰胺酶能力的 UPEC 菌株。该基因组序列及其产生的比较基因组学将有助于了解不同 UPEC 菌株的遗传构成，并促进新诊断方法/疫苗的开发。
