抗生素作为生物复杂性的探针。 - Suppr

Suppr

超能文献

Antibiotics as probes of biological complexity.

作者信息

Falconer Shannon B, Czarny Tomasz L, Brown Eric D

机构信息

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

出版信息

Nat Chem Biol. 2011 Jul;7(7):415-23. doi: 10.1038/nchembio.590.

DOI:10.1038/nchembio.590

PMID:21685879

Abstract

摘要

相似文献

Antibiotics as probes of biological complexity.抗生素作为生物复杂性的探针。

Nat Chem Biol. 2011 Jul;7(7):415-23. doi: 10.1038/nchembio.590.

[Bacteria: able to learn and adapt. Disease pathogens protect themselves through various resistance mechanisms].[细菌：能够学习和适应。疾病病原体通过各种抗性机制保护自身]

Med Monatsschr Pharm. 2006 Dec;29(12):430-2.

The two-competing site (TCS) model for cell shape regulation in bacteria: the envelope as an integration point for the regulatory circuits of essential physiological events.细菌细胞形态调控的双竞争位点（TCS）模型：作为基本生理事件调控回路整合点的细胞膜

Adv Microb Physiol. 1994;36:181-245. doi: 10.1016/s0065-2911(08)60180-0.

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.拓扑异构酶抑制剂解决革兰氏阴性菌中的氟喹诺酮类耐药性。

J Med Chem. 2020 Jul 23;63(14):7773-7816. doi: 10.1021/acs.jmedchem.0c00347. Epub 2020 Jul 7.

Glycopeptide resistance: Links with inorganic phosphate metabolism and cell envelope stress.糖肽类耐药性：与无机磷酸盐代谢和细胞包膜应激的关联。

Biochem Pharmacol. 2017 Jun 1;133:74-85. doi: 10.1016/j.bcp.2016.11.017. Epub 2016 Nov 25.

Cell Wall Deficiency as a Coping Strategy for Stress.细胞壁缺陷作为应对压力的一种策略。

Trends Microbiol. 2019 Dec;27(12):1025-1033. doi: 10.1016/j.tim.2019.07.008. Epub 2019 Aug 13.

Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents.细菌拓扑异构酶抑制剂：喹诺酮类和吡啶酮类抗菌剂。

Chem Rev. 2005 Feb;105(2):559-92. doi: 10.1021/cr030101q.

Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation.通过抑制持续性和适应性机制来对抗细菌和耐药性。

Nat Chem Biol. 2007 Sep;3(9):549-56. doi: 10.1038/nchembio.2007.27.

Mathematical modeling on bacterial resistance to multiple antibiotics caused by spontaneous mutations.关于自发突变导致细菌对多种抗生素耐药性的数学建模

Biosystems. 2014 Mar;117:60-7. doi: 10.1016/j.biosystems.2014.01.005. Epub 2014 Jan 24.

Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall.核糖体抑制抗生素氯霉素的衍生物可抑制细菌细胞壁的生物合成。

ACS Infect Dis. 2018 Jul 13;4(7):1121-1129. doi: 10.1021/acsinfecdis.8b00078. Epub 2018 May 1.

引用本文的文献

The physiology and genetics of bacterial responses to antibiotic combinations.细菌对抗生素组合的反应的生理学和遗传学。

Nat Rev Microbiol. 2022 Aug;20(8):478-490. doi: 10.1038/s41579-022-00700-5. Epub 2022 Mar 3.

Essential Genes of and Other spp. Guide the Development of New Drugs and Vaccines.[细菌名称]及其他[细菌名称]属的必需基因指导新型药物和疫苗的研发。（注：原文中两个[细菌名称]处需要根据实际所指细菌名称进行准确替换）

Front Microbiol. 2021 Oct 20;12:755801. doi: 10.3389/fmicb.2021.755801. eCollection 2021.

Understanding Beta-Lactam-Induced Lysis at the Single-Cell Level.在单细胞水平上理解β-内酰胺诱导的裂解

Front Microbiol. 2021 Jul 27;12:712007. doi: 10.3389/fmicb.2021.712007. eCollection 2021.

Mechanisms of drug interactions between translation-inhibiting antibiotics.翻译抑制抗生素相互作用的机制。

Nat Commun. 2020 Aug 11;11(1):4013. doi: 10.1038/s41467-020-17734-z.

Chemical tools for selective activity profiling of bacterial penicillin-binding proteins.用于细菌青霉素结合蛋白选择性活性分析的化学工具。

Methods Enzymol. 2020;638:27-55. doi: 10.1016/bs.mie.2020.02.015. Epub 2020 Apr 28.

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux.用于研究细菌渗透和外排的氟喹诺酮衍生荧光探针。

Medchemcomm. 2019 May 17;10(6):901-906. doi: 10.1039/c9md00124g. eCollection 2019 Jun 1.

Strong increase in the autofluorescence of cells signals struggle for survival.细胞自发荧光的强烈增加表明细胞正在为生存而挣扎。

Sci Rep. 2018 Aug 14;8(1):12088. doi: 10.1038/s41598-018-30623-2.

Novel Electrophilic Scaffold for Imaging of Essential Penicillin-Binding Proteins in Streptococcus pneumoniae.用于肺炎链球菌中必需青霉素结合蛋白成像的新型亲电支架

ACS Chem Biol. 2017 Nov 17;12(11):2849-2857. doi: 10.1021/acschembio.7b00614. Epub 2017 Oct 18.

The development of peptide ligands that target helix 69 rRNA of bacterial ribosomes.靶向细菌核糖体69号螺旋rRNA的肽配体的研发。

Bioorg Med Chem. 2016 Sep 15;24(18):4486-4491. doi: 10.1016/j.bmc.2016.07.050. Epub 2016 Jul 25.

New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.核糖体合成和翻译后修饰肽天然产物生物合成逻辑的新见解。

Cell Chem Biol. 2016 Jan 21;23(1):31-44. doi: 10.1016/j.chembiol.2015.11.012.

本文引用的文献

Phenotypic landscape of a bacterial cell.细菌细胞的表型景观。

Cell. 2011 Jan 7;144(1):143-56. doi: 10.1016/j.cell.2010.11.052. Epub 2010 Dec 23.

Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases.脂蛋白辅因子位于外膜上，可激活细菌细胞壁聚合酶。

Cell. 2010 Dec 23;143(7):1110-20. doi: 10.1016/j.cell.2010.11.037.

Regulation of peptidoglycan synthesis by outer-membrane proteins.外膜蛋白对肽聚糖合成的调控。

Cell. 2010 Dec 23;143(7):1097-109. doi: 10.1016/j.cell.2010.11.038.

Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system.大肠杆菌 ArfA（YhdL）在没有转译系统的情况下对核糖体的拯救。

Mol Microbiol. 2010 Nov;78(4):796-808. doi: 10.1111/j.1365-2958.2010.07375.x. Epub 2010 Sep 24.

Bacterial charity work leads to population-wide resistance.细菌慈善工作导致人群广泛耐药。

Nature. 2010 Sep 2;467(7311):82-5. doi: 10.1038/nature09354.

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.结核分枝杆菌 DNA 回旋酶喹诺酮类耐药机制的结构研究

PLoS One. 2010 Aug 18;5(8):e12245. doi: 10.1371/journal.pone.0012245.

Chemical probes of Escherichia coli uncovered through chemical-chemical interaction profiling with compounds of known biological activity.通过与已知生物活性化合物进行化学-化学相互作用分析发现的大肠杆菌化学探针。

Chem Biol. 2010 Aug 27;17(8):852-62. doi: 10.1016/j.chembiol.2010.06.008.

Type IIA topoisomerase inhibition by a new class of antibacterial agents.新型抗菌药物对 IIA 拓扑异构酶的抑制作用。

Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4.

Probing translation with small-molecule inhibitors.用小分子抑制剂探究翻译过程。

Chem Biol. 2010 Jun 25;17(6):633-45. doi: 10.1016/j.chembiol.2010.06.003.

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.万古霉素光探针鉴定组氨酸激酶 VanSsc 为万古霉素受体。

Nat Chem Biol. 2010 May;6(5):327-9. doi: 10.1038/nchembio.350. Epub 2010 Apr 11.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验