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BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2008.0200. Epub 2009 Feb 20.
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Intensive care of patients with HIV infection.HIV感染患者的重症监护
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Increasing likelihood of further live births in HIV-infected women in recent years.近年来，感染艾滋病毒的女性再次生育的可能性不断增加。
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Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy.抗逆转录病毒疗法，包括孕期高效抗逆转录病毒疗法，与改善产科结局及较少的母体毒性相关。
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U.S. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States.美国公共卫生服务部特别工作组关于在感染HIV-1的孕妇中使用抗逆转录病毒药物以促进孕产妇健康及采取干预措施减少美国围产期HIV-1传播的建议。
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Antiretroviral therapies in pregnancy: maternal, fetal and neonatal effects. Swiss HIV Cohort Study, the Swiss Collaborative HIV and Pregnancy Study, and the Swiss Neonatal HIV Study.孕期抗逆转录病毒疗法：对母亲、胎儿及新生儿的影响。瑞士HIV队列研究、瑞士HIV与妊娠协作研究以及瑞士新生儿HIV研究。
AIDS. 1998 Dec 24;12(18):F241-7. doi: 10.1097/00002030-199818000-00002.
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Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus.齐多夫定预防用药的简化方案与人免疫缺陷病毒的围产期传播
N Engl J Med. 1998 Nov 12;339(20):1409-14. doi: 10.1056/NEJM199811123392001.
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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.晚期人类免疫缺陷病毒感染患者的发病率和死亡率下降。HIV门诊研究调查人员。
N Engl J Med. 1998 Mar 26;338(13):853-60. doi: 10.1056/NEJM199803263381301.
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ACOG technical bulletin. Diabetes and pregnancy. Number 200--December 1994 (replaces No. 92, May 1986). Committee on Technical Bulletins of the American College of Obstetricians and Gynecologists.美国妇产科医师学会技术公报。糖尿病与妊娠。第200号——1994年12月（取代1986年5月的第92号）。美国妇产科医师学会技术公报委员会。
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一名感染了艾滋病毒且患有糖尿病肾病和视网膜病变的患者带来的重要临床经验。

An important clinical lesson from a patient infected with HIV with diabetic nephropathy and retinopathy.

作者信息

Martinelli Pasquale, Agangi Annalisa, Sansone Matilde, Napolitano Raffaele, Maruotti Giuseppe Maria

机构信息

University of Naples Federico II, Obstetrics and Gynecology, via Pansini, 5, Naples, 80131, Italy.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2008.0200. Epub 2009 Feb 20.

DOI:10.1136/bcr.06.2008.0200
PMID:21686901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3029002/
Abstract

In resource-rich settings, advances in antiretroviral therapy have reduced the morbidity and increased the life expectancy of patients infected with HIV and consequently increased the likelihood of observing other non-HIV-related diseases in this group of patients. We report a high-risk pregnancy in a 26-year-old woman infected with HIV with complicated insulin-dependent diabetes mellitus. Because of maternal concomitant disease and concerns regarding potential antiretroviral toxicity on maternal disease, an abbreviated regimen of zidovudine prophylaxis was offered to prevent neonatal infection. After the iatrogenic preterm delivery of a healthy and uninfected baby, the patient experienced vulvar oedema and she is now waiting for renal transplantation.In conclusion, our case is one of a range of possible scenarios that may develop in pregnant women who are infected with HIV, reflecting the highly active antiretroviral therapy (HAART)-associated improvements in survival and health.

摘要

在资源丰富的地区，抗逆转录病毒疗法的进展降低了HIV感染患者的发病率，提高了他们的预期寿命，因此在这组患者中观察到其他非HIV相关疾病的可能性增加。我们报告了一名26岁感染HIV且患有复杂的胰岛素依赖型糖尿病的高危孕妇病例。由于母亲合并疾病以及担心抗逆转录病毒药物对母亲疾病的潜在毒性，提供了一种简化的齐多夫定预防方案以预防新生儿感染。在医源性早产下一个健康且未感染的婴儿后，患者出现了外阴水肿，她现在正在等待肾移植。总之，我们的病例是感染HIV的孕妇可能出现的一系列情况之一，反映了高效抗逆转录病毒疗法（HAART）在生存和健康方面带来的改善。