Shevtsova Z V, Krylova R I, Lapin B A, Lomovskaia I B, Doroshenko N V, Belova E G
Zh Mikrobiol Epidemiol Immunobiol. 1991 Jun(6):68-73.
The prolonged (up to 2 years) complex observation of 11 rhesus macaques (Macaca mulatta) with spontaneous hepatitis A and 14 rhesus macaques with experimental hepatitis A developing after their intravenous and/or oral infection with human hepatitis A virus (HAV). Both natural and experimental infection took a chronic course (15-18 months). In 13 monkeys showing morphological changes in the liver during the whole period of the disease elevated enzyme levels in the blood and virus shedding in feces were periodically observed. Only one monkey had acute hepatitis A which lasted 1.5 months. In 11 monkeys the disease took an undulating course with 1-2 relapses when virological, biochemical and morphological signs of the disease could be detected. Seroconversion was observed in all monkeys. Anti-HAV IgM antibodies were retained for not more than 6-7 months and total anti-HAV antibodies, during the whole period of observation. Relapses were found to induce no antibody formation. Evidence on the prolonged (up to 12-16 months) persistence of HAV in primates was obtained for the first time.
对11只自然感染甲型肝炎的恒河猴（猕猴属）和14只经静脉和/或口服感染人甲型肝炎病毒（HAV）后发生实验性甲型肝炎的恒河猴进行了长达2年的综合观察。自然感染和实验感染均呈慢性病程（15 - 18个月）。在13只猴子中，在疾病的整个期间肝脏出现形态学变化，同时定期观察到血液中酶水平升高和粪便中病毒排出。只有一只猴子患了持续1.5个月的急性甲型肝炎。在11只猴子中，疾病呈波浪式病程，有1 - 2次复发，此时可检测到疾病的病毒学、生化和形态学体征。所有猴子均出现血清学转换。抗HAV IgM抗体在整个观察期间持续不超过6 - 7个月，总抗HAV抗体也如此。复发未诱导抗体形成。首次获得了甲型肝炎病毒在灵长类动物中持续存在长达12 - 16个月的证据。
