Tigenix Ltd., Byron House, Cambridge CB4 0WZ, UK.
Acta Biomater. 2011 Sep;7(9):3237-47. doi: 10.1016/j.actbio.2011.06.002. Epub 2011 Jun 13.
Collagen fibres are ubiquitous macromolecular assemblies in nature, providing the structures that support tensile mechanical loads within the human body. Aligned type I collagen fibres are the primary structural motif for tendon and ligament, and therefore biomaterials based on these structures are considered promising candidates for mediating regeneration of these tissues. However, despite considerable investigation, there remains no collagen-fibre-based biomaterial that has undergone clinical evaluation for this application. Recent research in this area has significantly enhanced our understanding of these complex and challenging biomaterials, and is reinvigorating interest in the development of such structures to recapitulate mechanical function. In this review we describe the progress to date towards a ligament or tendon regeneration template based on collagen fibre scaffolds. We highlight reports of particular relevance to the development of the underlying biomaterials science in this area. In addition, the potential for tailoring and manipulating the interactions between collagen fibres and biological systems, as hybrid biomaterial-biological ensembles, is discussed in the context of developing novel tissue engineering strategies for tendon and ligament.
胶原纤维是自然界中无处不在的高分子组装体，为人体提供承受拉伸机械载荷的结构。排列整齐的 I 型胶原纤维是肌腱和韧带的主要结构基元，因此基于这些结构的生物材料被认为是介导这些组织再生的有前途的候选物。然而，尽管进行了大量的研究，但仍然没有一种基于胶原纤维的生物材料经过这种应用的临床评估。该领域的最新研究极大地提高了我们对这些复杂且具有挑战性的生物材料的理解，并重新激发了开发此类结构以再现机械功能的兴趣。在这篇综述中，我们描述了基于胶原纤维支架的韧带或肌腱再生模板的最新进展。我们强调了与该领域基础生物材料科学发展特别相关的报告。此外，还讨论了在开发肌腱和韧带的新型组织工程策略的背景下，对胶原纤维与生物系统之间的相互作用进行定制和操纵的可能性，作为混合生物材料-生物联合体。
