Furuuchi S, Shimizu M, Shimizu Y
Natl Inst Anim Health Q (Tokyo). 1978 Winter;18(3-4):135-42.
Field trials were conducted on attenuated live virus vaccine of transmissible gastroenteritis to confer active immunity to newborn piglets. To examine innocuity and efficacy of the vaccine, a total of 714 newborn piglets were subjected to these trials. Of them, 357 piglets were administered orally with 10(7.0) TCID50 within 3 days after birth, and the other 357 piglets served as nonvaccinated controls. No undesirable postvaccinal reaction was observed in any vaccinated piglet. Suckling piglets born from nonimmune sows showed a good antibody response after vaccination. They were different, however, in antibody titer from one experimental place to another. Antibody levels were high in piglets raised in the northern experimental places. On the contrary, the antibody response of suckling piglets born from immune sows was influenced by vaccination. In most of these piglets, antibody titers declined markedly and disappeared finally 3 months after vaccination. About 25% of the non-vaccinated piglets showed an antibody response by pen contact with vaccinated ones.
对传染性胃肠炎减毒活疫苗进行了田间试验，以赋予新生仔猪主动免疫力。为检验该疫苗的安全性和有效性，共有714头新生仔猪接受了这些试验。其中，357头仔猪在出生后3天内口服10(7.0) TCID50，另外357头仔猪作为未接种疫苗的对照。在任何接种疫苗的仔猪中均未观察到不良的疫苗接种后反应。来自非免疫母猪的哺乳仔猪在接种疫苗后表现出良好的抗体反应。然而，它们在不同试验地点的抗体滴度有所不同。北方试验地点饲养的仔猪抗体水平较高。相反，来自免疫母猪的哺乳仔猪的抗体反应受疫苗接种的影响。在这些仔猪中的大多数中，抗体滴度在接种疫苗3个月后显著下降并最终消失。约25%的未接种疫苗仔猪通过与接种疫苗仔猪的栏舍接触而表现出抗体反应。
