亚利桑那州和加利福尼亚州球孢子菌病的公共卫生影响。

Global Health Sciences, University of California, San Francisco,1200 Beale St, #1200, San Francisco, CA 94105, USA.

Int J Environ Res Public Health. 2011 Apr;8(4):1150-73. doi: 10.3390/ijerph8041150. Epub 2011 Apr 15.

The numbers of reported cases of coccidioidomycosis in Arizona and California have risen dramatically over the past decade, with a 97.8% and 91.1% increase in incidence rates from 2001 to 2006 in the two states, respectively. Of those cases with reported race/ethnicity information, Black/African Americans in Arizona and Hispanics and African/Americans in California experienced a disproportionately higher frequency of disease compared to other racial/ethnic groups. Lack of early diagnosis continues to be a problem, particularly in suspect community-acquired pneumonia, underscoring the need for more rapid and sensitive tests. Similarly, the inability of currently available therapeutics to reduce the duration and morbidity of this disease underscores the need for improved therapeutics and a preventive vaccine.

过去十年中，亚利桑那州和加利福尼亚州的球孢子菌病报告病例数量急剧上升，这两个州的发病率分别在 2001 年至 2006 年期间增长了 97.8%和 91.1%。在报告种族/族裔信息的病例中，与其他种族/族裔群体相比，亚利桑那州的非裔美国人和加利福尼亚州的西班牙裔和非裔美国人患病频率不成比例地更高。早期诊断仍然是一个问题，特别是在疑似社区获得性肺炎中，这突显了需要更快速和敏感的检测方法。同样，目前可用的治疗方法无法缩短该疾病的持续时间和降低发病率，这也突显了需要改进治疗方法和预防疫苗。