Mathew Revi P, Moore Daniel J
Monore Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232-9170, USA.
Clin Pediatr (Phila). 2011 Nov;50(11):1040-4. doi: 10.1177/0009922811412583. Epub 2011 Jun 23.
Two children presented with autoimmune alternating hypo- and hyperthyroidism related to the presence of blocking and stimulating thyroid antibodies. It was difficult to control their thyroid function adequately with an appropriate single drug regimen, and both children underwent total thyroidectomy with subsequent stable management with levothyroxine replacement therapy postsurgically. Although this phenomenon is well described in adults, this report is the first of such occurrence in children. The possible mechanism for the variation in the type of clinical presentation and options for management are discussed.
两名儿童因存在甲状腺阻断抗体和刺激抗体而出现自身免疫性交替性甲状腺功能减退和亢进。采用适当的单一药物治疗方案很难充分控制他们的甲状腺功能，两名儿童均接受了甲状腺全切除术，术后通过左甲状腺素替代疗法进行稳定管理。虽然这种现象在成人中已有充分描述，但本报告是儿童中首例此类病例。本文讨论了临床表现类型变化的可能机制及治疗选择。
