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伊曲康唑,一种新型口服活性抗真菌药,用于治疗花斑癣。

Itraconazole, a new orally active antifungal, in the treatment of pityriasis versicolor.

作者信息

Delescluse J, Cauwenbergh G, Degreef H

出版信息

Br J Dermatol. 1986 Jun;114(6):701-3. doi: 10.1111/j.1365-2133.1986.tb04879.x.

DOI:10.1111/j.1365-2133.1986.tb04879.x
PMID:3013271
Abstract

Itraconazole, a new orally active triazole antifungal, has been tested in patients with pityriasis versicolor. A comparison of different dose schedules was carried out in 73 patients. A regime of 100 mg itraconazole daily for 15 days gave a 100% response rate; 200 mg daily for 5 days gave an 80% response rate. Two patients, who had received 50 mg itraconazole for 14 days, relapsed within 2 months of finishing treatment. Only two patients reported minor side-effects.

摘要

伊曲康唑是一种新型口服活性三唑类抗真菌药,已在花斑癣患者中进行了试验。对73例患者进行了不同给药方案的比较。每天服用100毫克伊曲康唑,持续15天的方案有效率为100%;每天服用200毫克,持续5天的方案有效率为80%。两名接受50毫克伊曲康唑治疗14天的患者在完成治疗后2个月内复发。只有两名患者报告有轻微副作用。

相似文献

1
Itraconazole, a new orally active antifungal, in the treatment of pityriasis versicolor.伊曲康唑,一种新型口服活性抗真菌药,用于治疗花斑癣。
Br J Dermatol. 1986 Jun;114(6):701-3. doi: 10.1111/j.1365-2133.1986.tb04879.x.
2
Itraconazole in tinea versicolor: a review.伊曲康唑治疗花斑癣的综述
J Am Acad Dermatol. 1990 Sep;23(3 Pt 2):551-4. doi: 10.1016/0190-9622(90)70252-d.
3
Itraconazole in pityriasis versicolor.伊曲康唑治疗花斑糠疹。
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S128-30. doi: 10.1093/clinids/9.supplement_1.s128.
4
[Itraconazole in the treatment of pityriasis versicolor: comparison between 5 and 7 days of treatment].伊曲康唑治疗花斑糠疹:5天与7天治疗的比较
Rev Inst Med Trop Sao Paulo. 1990 May-Jun;32(3):181-4.
5
Pityriasis versicolor: efficacy of two five-day regimens of itraconazole.花斑糠疹:两种伊曲康唑五日疗法的疗效
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S131-3. doi: 10.1093/clinids/9.supplement_1.s131.
6
Itraconazole in pityriasis versicolor: ultrastructural changes in Malassezia furfur produced during treatment.伊曲康唑治疗花斑糠疹:治疗期间马拉色菌的超微结构变化
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S134-8. doi: 10.1093/clinids/9.supplement_1.s134.
7
Treatment of dermatophytoses and pityriasis versicolor with itraconazole.伊曲康唑治疗皮肤癣菌病和花斑癣
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S109-13. doi: 10.1093/clinids/9.supplement_1.s109.
8
Itraconazole therapy in pityriasis versicolor.伊曲康唑治疗花斑糠疹。
Br J Dermatol. 1986 Aug;115(2):217-25. doi: 10.1111/j.1365-2133.1986.tb05721.x.
9
Treatment of pityriasis versicolor with itraconazole.伊曲康唑治疗花斑糠疹
Mykosen. 1987 Jan;30(1):44-7.
10
Itraconazole in the treatment of superficial mycoses--a double-blind study vs. placebo.伊曲康唑治疗浅表真菌病——与安慰剂对照的双盲研究
Clin Exp Dermatol. 1990 Mar;15(2):101-4. doi: 10.1111/j.1365-2230.1990.tb02041.x.

引用本文的文献

1
Itraconazole vs amphotericin B: in vitro comparative evaluation of the minimal inhibitory concentration (MIC) against clinically isolated yeasts.伊曲康唑与两性霉素B:针对临床分离酵母的最低抑菌浓度(MIC)的体外比较评估
Mycopathologia. 1989 Apr;106(1):31-4. doi: 10.1007/BF00436923.
2
The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects.食物和剂量对健康受试者中伊曲康唑口服全身可用性的影响。
Eur J Clin Pharmacol. 1989;36(4):423-6. doi: 10.1007/BF00558308.
3
Itraconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses.
伊曲康唑。对其药效学和药代动力学特性以及在浅表和全身性真菌病治疗中的应用进行综述。
Drugs. 1989 Mar;37(3):310-44. doi: 10.2165/00003495-198937030-00003.