Department of ENT, Stavanger University Hospital, PB 8100, 4068 Stavanger, Norway.
Eur Arch Otorhinolaryngol. 2012 Jan;269(1):121-5. doi: 10.1007/s00405-011-1675-y. Epub 2011 Jun 26.
Though some data indicate an association between gastroesophageal reflux disease (GERD) and upper airway inflammatory disease, a connection between GERD and chronic rhinosinusitis (CRS) is a matter of controversy in today's medicine. The aim of this study was to examine whether patients with GERD have a different nose- and sinus-related quality of life compared to a control group. A total of 77 patients with GERD diagnosed by gastroscopy were evaluated according to their nose- and sinus-related quality of life. It was scored using the Sino-Nasal Outcome Test-20 (SNOT-20). Total SNOT-20 score was compared with a control group consisting of 480 teachers. The average total SNOT-20 score in patients with GERD was 22.1, and in the control group 9.4 (p < 0.005). In the patient group, the median was 17.0 and standard deviation 18.4 corresponding to 5.0 and 11.5 in the controls. The 95% confidence interval in the patient group was (18.0, 26.3), and (8.3, 10.4) in the control group. Patients with GERD have a reduced nose- and sinus-related quality of life compared to a control group based on the fact that they have a significantly higher total SNOT-20 score than the controls. Accordingly, this study indicates that there is a causal relationship between GERD and CRS.
尽管一些数据表明胃食管反流病（GERD）与上呼吸道炎症性疾病之间存在关联，但 GERD 与慢性鼻-鼻窦炎（CRS）之间的联系在当今医学中仍存在争议。本研究旨在探讨 GERD 患者与对照组相比是否存在不同的鼻部和鼻窦相关生活质量。通过胃镜检查诊断为 GERD 的 77 例患者根据其鼻部和鼻窦相关生活质量进行评估。使用 Sino-Nasal Outcome Test-20（SNOT-20）进行评分。总 SNOT-20 评分与由 480 名教师组成的对照组进行比较。GERD 患者的平均总 SNOT-20 评分为 22.1，对照组为 9.4（p<0.005）。在患者组中，中位数为 17.0，标准差为 18.4，相应的对照组为 5.0 和 11.5。患者组的 95%置信区间为（18.0，26.3），对照组为（8.3，10.4）。与对照组相比，GERD 患者的鼻部和鼻窦相关生活质量降低，因为他们的总 SNOT-20 评分明显高于对照组。因此，本研究表明 GERD 与 CRS 之间存在因果关系。
