The Foundation for Medical Research, Worli, Mumbai, India.
Indian J Pharmacol. 2011 May;43(3):340-4. doi: 10.4103/0253-7613.81502.
To study the antidiarrheal activity of the decoction of Cyperus rotundus Linn. tubers using representative assays of diarrheal pathogenesis and understand its mechanism of action.Antibacterial, antigiardial and antirotaviral activities were studied. Effect on adherence of enteropathogenic Escherichia coli (EPEC) and invasion of enteroinvasive E. coli (EIEC) and Shigella flexneri to HEp-2 cells was evaluated as a measure of effect on colonization. Effect on enterotoxins such as enterotoxigenic E. coli (ETEC) heat labile toxin (LT), heat stable toxin (ST) and cholera toxin (CT) was also assessed. The decoction showed antigiardial activity, reduced bacterial adherence to and invasion of HEp-2 cells and affected production of CT and action of LT. The decoction of C. rotundus does not have marked antimicrobial activity and exerts its antidiarrheal action by mechanisms other than direct killing of the pathogen.
为了研究香附块茎汤对腹泻发病机制的代表性检测的抗腹泻活性，并了解其作用机制。研究了其抗菌、抗贾第鞭毛虫和抗轮状病毒的活性。作为定植效果的衡量标准，评估了对肠致病性大肠杆菌（EPEC）和侵袭性大肠杆菌（EIEC）和志贺氏菌黏附到 HEp-2 细胞以及入侵的影响。还评估了对肠毒素如产肠毒性大肠杆菌（ETEC）不耐热毒素（LT）、耐热毒素（ST）和霍乱毒素（CT）的影响。该汤剂显示出抗贾第鞭毛虫活性，减少了细菌对 HEp-2 细胞的黏附和入侵，并影响了 CT 的产生和 LT 的作用。香附汤没有明显的抗菌活性，通过直接杀死病原体以外的机制发挥其抗腹泻作用。
