Moghadasi Nargess, Alimohammadi Iraj, Safari Variani Ali, Ashtarinezhad Azadeh
Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Occupational Health Engineering, School of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran.
J Family Reprod Health. 2021 Sep;15(3):172-178. doi: 10.18502/jfrh.v15i3.7134.
Due to the growing use of communication instruments such as cell phones and wireless devices, there is growing public concern about possible harmful effects, especially in sensitive groups such as pregnant women. This study aimed to investigate the oxidative stress induced by exposure to 900 MHz mobile phone radiation and the effect of vitamin C intake on reducing possible changes in pregnant mice. Twenty-one pregnant mice were divided into three groups (control, mobile radiation-exposed, and mobile radiation plus with vitamin C intake co-exposed (200 mg /kg)). The mice in exposure groups were exposed to 900 MHz, 2 watts, and a power density of 0.045 μw /cm mobile radiation for eight hours/day for ten consecutive days. After five days of rest, MDA (Malondialdehyde), 8-OHdG (8-hydroxy-2' -deoxyguanosine), and TAC (Total Antioxidant Capacity) levels were measured in the blood of animals. The results were analyzed by SPSS.22.0 software. The results showed that exposure to mobile radiation increased MDA (P=0.002), and 8-OHdG (P=0.001) significantly and decreased Total Antioxidant Capacity in the exposed groups (P=0.001). Taking vitamin C inhibited the significant increase in MDA and 8-OHdG levels in exposed groups. Although exposure to mobile radiation can cause oxidative stress in the blood of pregnant mice, vitamin C as an antioxidant can prevent it.
由于手机和无线设备等通信工具的使用日益增加，公众对其可能产生的有害影响愈发关注，尤其是对孕妇等敏感群体。本研究旨在调查暴露于900兆赫手机辐射所诱导的氧化应激以及摄入维生素C对减轻怀孕小鼠可能出现的变化的影响。将21只怀孕小鼠分为三组（对照组、暴露于手机辐射组、暴露于手机辐射并同时摄入维生素C组（200毫克/千克））。暴露组的小鼠连续10天每天暴露于900兆赫、2瓦、功率密度为0.045微瓦/平方厘米的手机辐射下8小时。休息5天后，测量动物血液中的丙二醛（MDA）、8-羟基-2'-脱氧鸟苷（8-OHdG）和总抗氧化能力（TAC）水平。结果采用SPSS 22.0软件进行分析。结果显示，暴露于手机辐射显著增加了暴露组的丙二醛（P = 0.002）和8-羟基-2'-脱氧鸟苷（P = 0.001）水平，并降低了总抗氧化能力（P = 0.001）。摄入维生素C抑制了暴露组丙二醛和8-羟基-2'-脱氧鸟苷水平的显著升高。尽管暴露于手机辐射会在怀孕小鼠的血液中引起氧化应激，但维生素C作为一种抗氧化剂可以预防这种情况。
