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介孔硅纳米粒子作为纳米载体。

Mesoporous silica nanoparticles as nanocarriers.

机构信息

Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan 10617.

出版信息

Chem Commun (Camb). 2011 Sep 28;47(36):9972-85. doi: 10.1039/c1cc11760b. Epub 2011 Jun 29.

Abstract

Modern nanomedicine aims at delivering drugs or cells specifically to defective cells; therefore, this calls for developing multifunctional nanocarriers for drug delivery and cell-tracking. Mesoporous silica nanoparticles (MSNs) are well suited for this task. In this feature article, we highlight the strategies in the synthesis and functionalization of small, uniform and colloidal stable MSNs. We then discuss cell uptake of MSNs and tracking cells, as both aspects are closely related to the efficacy of drug delivery and theranostics. Some examples of stimulated drug delivery are described. For application considerations, toxicity and pharmacokinetics are critical issues and in vivo studies are summarized.

摘要

现代纳米医学旨在将药物或细胞特异性递送到病变细胞;因此,这需要开发用于药物递送和细胞跟踪的多功能纳米载体。介孔硅纳米粒子(MSNs)非常适合这项任务。在这篇专题文章中,我们强调了在合成和功能化小、均一和胶体稳定的 MSNs 方面的策略。然后,我们讨论了 MSNs 的细胞摄取和细胞跟踪,因为这两个方面都与药物递送和治疗的疗效密切相关。描述了一些刺激药物释放的例子。对于应用考虑,毒性和药代动力学是关键问题,并总结了体内研究。

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