Devoĭno L V, Idova G V, Beletskaia I O
Fiziol Zh SSSR Im I M Sechenova. 1990 Jun;76(6):808-12.
In CBA mice immunized with the sheep red blood cells (5 x 10(8)), the section of the pituitary stalk prevented the changes in the immune response caused with drugs affecting the activity of GABA-ergic system. Activating effect of the benzodiazepine receptor agonist diazepam, and inhibitory effect of bicucullin on the immune response were not manifest in animals after the lesion of the hypothalamo-pituitary stalk. The mechanism of increasing of the L3T4 T-helpers in bone marrow under the effect of GABA-ergic system activity was also actualized through the hypophysis. The central GABA-ergic mechanisms of the neuroimmunomodulation are discussed.
在用绵羊红细胞（5×10⁸）免疫的CBA小鼠中，垂体柄切断可阻止因影响γ-氨基丁酸（GABA）能系统活性的药物所引起的免疫反应变化。在丘脑下部-垂体柄损伤后的动物中，苯二氮䓬受体激动剂地西泮的激活作用以及荷包牡丹碱对免疫反应的抑制作用均未表现出来。GABA能系统活性影响下骨髓中L3T4辅助性T细胞增加的机制也通过垂体得以实现。本文讨论了神经免疫调节的中枢GABA能机制。
