Department of Applied Sciences in Biosystems, University of Cagliari, Cagliari, Italy.
Nat Prod Res. 2011 Jul;25(11):1067-73. doi: 10.1080/14786419.2010.508896.
The hydroalcoholic extract obtained from the seeds of Casimiroa edulis cultivated in Sardinia (Italy) have been assayed on the two enzymatic-associated activities of the HIV-1 reverse transcriptase (RT), the RNA-dependent DNA polymerase (RDDP) and the ribonuclease H. In biochemical assays, the extract inhibited both activities in a dose-dependent manner, showing a 10-fold more potent inhibition of the HIV-1 RT RDDP activity. Furthermore, the extract was cytotoxic on K562 cell replication.
从意大利撒丁岛种植的 Casimiroa edulis 种子中提取的水醇提取物已对 HIV-1 逆转录酶（RT）的两种与酶相关的活性、RNA 依赖性 DNA 聚合酶（RDDP）和核糖核酸酶 H 进行了检测。在生化检测中，提取物呈剂量依赖性抑制两种活性，对 HIV-1 RT RDDP 活性的抑制作用强 10 倍。此外，提取物对 K562 细胞复制具有细胞毒性。
