Lucassen Peter
Department of General Practice, Radbound University Nijmegen, Nijmegen, The Netherlands.
BMJ Clin Evid. 2010 Feb 5;2010:0309.
Colic in infants causes one in six families (17%) with children to consult a health professional. One systematic review of 15 community-based studies found a wide variation in prevalence, which depended on study design and method of recording.
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for colic in infants? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found 27 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: advice to increase carrying, advice to reduce stimulation, casein hydrolysate milk, cranial osteopathy, crib vibrator device, focused counselling, gripe water, infant massage, low-lactose milk, simethicone, soya-based infant feeds, spinal manipulation, and whey hydrolysate milk.
婴儿腹绞痛导致六分之一（17%）有孩子的家庭向健康专家咨询。一项对15项基于社区的研究的系统评价发现，患病率差异很大，这取决于研究设计和记录方法。
我们进行了一项系统评价，旨在回答以下临床问题：婴儿腹绞痛治疗方法的效果如何？我们检索了：截至2009年9月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（《临床证据》综述会定期更新，请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品及医疗保健产品监管局（MHRA）等相关组织的危害警示。
我们找到了27项符合我们纳入标准的系统评价、随机对照试验或观察性研究。我们对干预措施证据的质量进行了GRADE评估。
在本系统评价中，我们提供了以下干预措施的有效性和安全性相关信息：增加抱婴时间的建议、减少刺激的建议、酪蛋白水解物配方奶、颅骨整骨疗法、婴儿床振动装置、针对性咨询、驱风剂、婴儿按摩、低乳糖配方奶、西甲硅油、大豆基婴儿配方奶、脊柱推拿以及乳清蛋白水解物配方奶。
