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从由聚（d，l-丙交酯）（PDLLA）和聚环氧乙烷（PEO）组合制备的纳米纤维中释放细菌素。

Release of bacteriocins from nanofibers prepared with combinations of poly(d,l-lactide) (PDLLA) and poly(ethylene oxide) (PEO).

作者信息

Heunis Tiaan, Bshena Osama, Klumperman Bert, Dicks Leon

机构信息

Department of Microbiology, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa; E-Mail:

出版信息

Int J Mol Sci. 2011;12(4):2158-73. doi: 10.3390/ijms12042158. Epub 2011 Mar 29.

DOI:10.3390/ijms12042158
PMID:21731433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3127109/
Abstract

Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(d,l-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.

摘要

植物乳杆菌产生的植物乳杆菌素423和蒙氏肠球菌产生的细菌素ST4SA被静电纺丝到由溶解于N，N-二甲基甲酰胺（DMF）中的聚（d，l-丙交酯）（PDLLA）和聚环氧乙烷（PEO）的不同组合制备的纳米纤维中。两种肽均从纳米纤维中以高初始突释释放，并在37℃下保留其原始抗菌活性的88％。纳米纤维有潜力作为细菌素的载体基质，并为开发用于各种应用的可控抗菌递送系统开辟一个新领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4859/3127109/002497e242d8/ijms-12-02158f8.jpg
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