Heunis Tiaan, Bshena Osama, Klumperman Bert, Dicks Leon
Department of Microbiology, University of Stellenbosch, 7602 Matieland (Stellenbosch), South Africa; E-Mail:
Int J Mol Sci. 2011;12(4):2158-73. doi: 10.3390/ijms12042158. Epub 2011 Mar 29.
Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(d,l-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 °C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.
植物乳杆菌产生的植物乳杆菌素423和蒙氏肠球菌产生的细菌素ST4SA被静电纺丝到由溶解于N，N-二甲基甲酰胺（DMF）中的聚（d，l-丙交酯）（PDLLA）和聚环氧乙烷（PEO）的不同组合制备的纳米纤维中。两种肽均从纳米纤维中以高初始突释释放，并在37℃下保留其原始抗菌活性的88％。纳米纤维有潜力作为细菌素的载体基质，并为开发用于各种应用的可控抗菌递送系统开辟一个新领域。
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