Sinsup Pattawika, Teeranachaideekul Veerawat, Makarasen Arthit, Chuenchom Laemthong, Prajongtat Pongthep, Techasakul Supanna, Yingyuad Peerada, Dechtrirat Decha
Department of Materials Science, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Membranes (Basel). 2021 Aug 24;11(9):648. doi: 10.3390/membranes11090648.
The essential oil from Roxb. () has long been used in Thai herbal remedies to treat inflammation, pains, sprains, and wounds. It was therefore loaded into an electrospun fibrous membrane for use as an analgesic and antibacterial dressing for wound care. The polymer blend between poly(lactic acid) and poly(ethylene oxide) was selected as the material of choice because its wettability can be easily tuned by changing the blend ratio. Increasing the hydrophilicity and water uptake ability of the material while retaining its structural integrity and porosity provides moisture balance and removes excess exudates, thereby promoting wound healing. The effect of the blend ratio on the fiber morphology and wettability was investigated using scanning electron microscopy (SEM) and contact angle measurement, respectively. The structural determination of the prepared membranes was conducted using Fourier-transform infrared spectroscopy (FTIR). The release behavior of (E)-1-(3,4-dimethoxyphenyl) butadiene (DMPBD), a marker molecule with potent anti-inflammatory activity from the fiber blend, showed a controlled release characteristic. The essential oil-loaded electrospun membrane also showed antibacterial activity against and . It also exhibited no toxicity to both human fibroblast and keratinocyte cells, suggesting that the prepared material is suitable for wound dressing application.
来自罗克斯伯里（Roxb.）的精油长期以来一直被用于泰国草药疗法中，以治疗炎症、疼痛、扭伤和伤口。因此，它被载入静电纺丝纤维膜中，用作伤口护理的止痛和抗菌敷料。选择聚乳酸和聚环氧乙烷之间的聚合物共混物作为首选材料，因为其润湿性可以通过改变共混比例轻松调节。在保持材料结构完整性和孔隙率的同时提高其亲水性和吸水能力，可提供水分平衡并去除多余的渗出物，从而促进伤口愈合。分别使用扫描电子显微镜（SEM）和接触角测量研究了共混比例对纤维形态和润湿性的影响。使用傅里叶变换红外光谱（FTIR）对制备的膜进行结构测定。来自纤维共混物的具有强大抗炎活性的标记分子（E）-1-（3,4-二甲氧基苯基）丁二烯（DMPBD）的释放行为显示出控释特性。负载精油的静电纺丝膜对[具体细菌名称1]和[具体细菌名称2]也显示出抗菌活性。它对人成纤维细胞和角质形成细胞均无毒性，表明所制备的材料适用于伤口敷料应用。
