Department of Cardiac Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
Stem Cells. 2011 Feb;29(2):163-8. doi: 10.1002/stem.583.
Solid tumors are complex "organs" of cancer cells and a heterogeneous population of hematopoietic cells, mesenchymal cells, and endothelial cells. The cancer stem cell model proposes that tumor growth and progression is driven by rare populations of cancer stem cells; however, nontumor-forming stem and progenitor cells are also present within the tumor microenvironment. These adult stem cells do not form tumors when injected into experimental animals, but they may augment tumor growth through juxtacrine and paracrine regulation of tumor cells and by contributing to neovascularization. Thus, cancer cells may actively co-opt nontumor-forming stem cells distally from the bone marrow or proximally from nearby tissue and subvert their abilities to differentiate and maintain tissue growth, repair, and angiogenesis. This review will cover the roles of nontumor-forming vascular stem cells in tumor growth and angiogenesis.
实体瘤是癌细胞和异质性造血细胞、间充质细胞和内皮细胞的复杂“器官”。癌症干细胞模型提出，肿瘤的生长和进展是由罕见的癌症干细胞群体驱动的；然而，肿瘤微环境中也存在非肿瘤形成的干细胞和祖细胞。这些成体干细胞在注射到实验动物中时不会形成肿瘤，但它们可能通过旁分泌和自分泌调节肿瘤细胞，以及通过促进新生血管生成来促进肿瘤生长。因此，癌细胞可能会主动从远离骨髓的部位或从附近组织的近端招募非肿瘤形成的干细胞，并破坏它们分化和维持组织生长、修复和血管生成的能力。这篇综述将涵盖非肿瘤形成的血管干细胞在肿瘤生长和血管生成中的作用。
