金纳米粒子的光诱导 DNA 释放：纳米壳和纳米棒。
Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.
机构信息
Department of Chemistry, Rice University, Houston, Texas 77005, USA.
出版信息
J Am Chem Soc. 2011 Aug 10;133(31):12247-55. doi: 10.1021/ja204578e. Epub 2011 Jul 20.
Abstract
Plasmon-resonant nanoparticle complexes show highly promising potential for light-triggered, remote-controlled delivery of oligonucleotides on demand, for research and therapeutic purposes. Here we investigate the light-triggered release of DNA from two types of nanoparticle substrates: Au nanoshells and Au nanorods. Both light-triggered and thermally induced release are distinctly observable from nanoshell-based complexes, with light-triggered release occurring at an ambient solution temperature well below the DNA melting temperature. Surprisingly, no analogous measurable release was observable from nanorod-based complexes below the DNA melting temperature. These results suggest that a nonthermal mechanism may play a role in plasmon resonant, light-triggered DNA release.
摘要
等离子体共振纳米粒子复合物在按需、远程控制寡核苷酸的光触发传递方面具有很高的应用潜力，可用于研究和治疗目的。在这里，我们研究了两种类型的纳米粒子基底：金纳米壳和金纳米棒，从它们的复合物中光触发释放 DNA。从纳米壳复合物中可以明显观察到光触发释放和热诱导释放，而在环境溶液温度远低于 DNA 熔点的情况下，光触发释放就会发生。令人惊讶的是，在低于 DNA 熔点的情况下，从基于纳米棒的复合物中观察不到类似的可测量释放。这些结果表明，非热机制可能在等离子体共振光触发 DNA 释放中起作用。
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