一项针对 30 万名老年人中久坐时间与肾细胞癌风险的前瞻性分析。
A prospective analysis of prolonged sitting time and risk of renal cell carcinoma among 300,000 older adults.
机构信息
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
出版信息
Ann Epidemiol. 2011 Oct;21(10):787-90. doi: 10.1016/j.annepidem.2011.04.012. Epub 2011 Jul 7.
PURPOSE
Accumulating evidence suggests an etiologic role in renal cell carcinoma (RCC) for physical activity. However, it is unknown if prolonged sitting, which is thought to be distinct from too little moderate-vigorous physical activity, is an independent risk factor for RCC. The authors prospectively examined the relationship of prolonged sitting and risk of RCC among 289,512 women and men in the National Institutes of Health-AARP Diet and Health Study.
METHODS
From 1996 through 2006, 1206 invasive RCC cancer cases were identified. Cox proportional hazards regression was used to estimate multivariate hazard ratios (HR) and 95% confidence intervals.
RESULTS
After controlling for known risk factors for RCC, we did not find evidence of associations between RCC risk and time spent per day sitting while watching television or videos (HR(7 + hrs: < 1 hr) = 0.96 (0.66, 1.38); p trend = 0.707) or total sitting time (HR(9 + hrs: < 3 hrs) = 1.11 (0.87, 1.41); p trend = 0.765).
CONCLUSIONS
Prolonged sitting time was not associated with RCC risk among men and women in this large cohort.
目的
越来越多的证据表明体力活动在肾细胞癌（RCC）发病机制中起作用。然而，目前尚不清楚长时间坐着（被认为与适度剧烈体力活动不足不同）是否是 RCC 的独立危险因素。作者前瞻性地研究了美国国立卫生研究院-美国退休人员协会饮食与健康研究中 289512 名女性和男性中长时间坐着与 RCC 风险的关系。
方法
1996 年至 2006 年间，确定了 1206 例侵袭性 RCC 癌症病例。采用 Cox 比例风险回归估计多变量风险比（HR）和 95%置信区间。
结果
在控制 RCC 的已知危险因素后，我们没有发现 RCC 风险与每天坐着看电视或视频的时间（HR（7+ 小时：<1 小时）= 0.96（0.66，1.38）；p 趋势= 0.707）或总坐姿时间（HR（9+ 小时：<3 小时）= 1.11（0.87，1.41）；p 趋势= 0.765）之间存在关联的证据。
结论
在这项大型队列研究中，长时间坐着与男性和女性的 RCC 风险无关。
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