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Plus-strand origin for human immunodeficiency virus type 1: implications for integration.

作者信息

Pullen K A, Champoux J J

机构信息

Department of Microbiology, School of Medicine, University of Washington, Seattle 98195.

出版信息

J Virol. 1990 Dec;64(12):6274-7. doi: 10.1128/JVI.64.12.6274-6277.1990.

DOI:10.1128/JVI.64.12.6274-6277.1990
PMID:2173791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248804/
Abstract

The start site for human immunodeficiency virus type 1 plus strands within the polypurine tract was mapped by an in vitro analysis to the sequence 5'-ACTG....From this result, it can be inferred that integration of human immunodeficiency virus type 1 must be accompanied by the loss of two base pairs from the polypurine tract-primed long terminal repeat end.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2928/248804/0cd9cfdda091/jvirol00067-0594-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2928/248804/0cd9cfdda091/jvirol00067-0594-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2928/248804/0cd9cfdda091/jvirol00067-0594-a.jpg

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本文引用的文献

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Cell. 1984 Mar;36(3):673-9. doi: 10.1016/0092-8674(84)90347-7.
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The terminal nucleotides of retrovirus DNA are required for integration but not virus production.逆转录病毒DNA的末端核苷酸是整合所必需的，但不是病毒产生所必需的。
Nature. 1983;306(5939):155-60. doi: 10.1038/306155a0.
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Cutting of M13mp7 phage DNA and excision of cloned single-stranded sequences by restriction endonucleases.用限制性内切核酸酶切割M13mp7噬菌体DNA并切除克隆的单链序列。
HIV-1 逆转录酶的核糖核酸酶 H 活性被 GSK5750 抑制与缓慢的酶-抑制剂解离相关。
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Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.单体逆转录病毒逆转录酶与 RNA/DNA 杂交复合物的结构分析。
Nucleic Acids Res. 2013 Apr 1;41(6):3874-87. doi: 10.1093/nar/gkt053. Epub 2013 Feb 4.
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HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.HIV-1 核糖核酸酶 H：结构、催化机制与抑制剂。
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HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.HIV-1逆转录酶可在DNA聚合酶和核糖核酸酶H活性位点同时结合其DNA/RNA底物：对核糖核酸酶H抑制的影响。
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RNA-primed initiation of Moloney murine leukemia virus plus strands by reverse transcriptase in vitro.逆转录酶在体外以RNA为引物起始莫洛尼鼠白血病病毒正链的合成
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