Jelicks Linda A
Department of Physiology & Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
J Neuroparasitology. 2010 Jan 1;1. doi: 10.4303/jnp/N100504.
Animal models of human diseases are increasingly available and are invaluable for studies of organ pathophysiology. Megacolon, abnormal dilatation of the colon not caused by mechanical obstruction, involves the destruction of the autonomic nervous system innervating the colon. Animal models of megacolon include mouse models of Chagas disease and Hirschprung's disease. Small animal imaging has become an important research tool and recent advances in preclinical imaging modalities have enhanced the information content available from longitudinal studies of animal models of human diseases. While numerous applications of imaging technologies have been reported to study the brain and heart of mouse models, fewer studies of the gastrointestinal system have been undertaken due to technical limitations caused by peristaltic and respiratory motion. Various imaging modalities relevant to study of the gastrointestinal tract of intact live animals are reviewed herein.
人类疾病的动物模型越来越多，对于器官病理生理学研究而言价值非凡。巨结肠是指结肠的异常扩张，并非由机械性梗阻引起，它涉及支配结肠的自主神经系统的破坏。巨结肠的动物模型包括恰加斯病和先天性巨结肠病的小鼠模型。小动物成像已成为一项重要的研究工具，临床前成像模式的最新进展增加了从人类疾病动物模型纵向研究中获得的信息量。虽然已有大量关于成像技术在小鼠模型脑和心脏研究中的应用报道，但由于蠕动和呼吸运动造成的技术限制，对胃肠道系统的研究较少。本文综述了与完整活体动物胃肠道研究相关的各种成像模式。
