卷曲蛋白的分子结构，一种果蝇组织极性基因。
Molecular structure of frizzled, a Drosophila tissue polarity gene.
作者信息
Adler P N, Vinson C, Park W J, Conover S, Klein L
机构信息
Biology Department, University of Virginia, Charlottesville 22901.
出版信息
Genetics. 1990 Oct;126(2):401-16. doi: 10.1093/genetics/126.2.401.
Abstract
The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is encoded by 5 exons spread over more than 90 kb of genomic DNA. Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains.
摘要
卷曲（fz）基因座的功能对于协调蛹表皮细胞的细胞骨架至关重要，从而产生平行排列的表皮毛和刚毛。我们在此报告fz基因座的分子克隆和特征。该基因座非常大。使该基因失活的突变分布在100 kb的基因组DNA上。该基因的主要mRNA产物是一种4 kb的RNA，由分布在超过90 kb基因组DNA上的5个外显子编码。对该mRNA进行概念性翻译表明，它编码一种整合膜蛋白，可能同时包含细胞外结构域和细胞质结构域。
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