Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Nat Prod Res. 2011 Jul;25(12):1171-9. doi: 10.1080/14786419.2010.490782.
The antihyperglycaemic and hypolipidaemic effects of the methanolic extract of Caralluma tuberculata were investigated in streptozotocin (STZ)-induced diabetic rats. The antihyperglycaemic activity was assessed by the reduction in fasting blood glucose (54% at 4th week) and the peak of blood glucose at 120?min of an oral glucose tolerance test in diabetic rats. Further, the tested extract also increased plasma insulin by 206.8%. The hypolipidaemic action of the extract was evident by the significant decrease in the levels of total cholesterol, triglycerides and LDL-cholesterol by 41.5%, 36.7% and 49.1%, respectively, compared to diabetic rat values. Interestingly, the extract increased the cardio-protective lipid HDL-cholesterol by 147.97% as compared to diabetic rat value. The present data suggests that the methanolic extract of C. tuberculata has both antihyperglycaemic and hypolipidaemic effects in STZ-induced diabetic rats that may need further studies to be used in the management of diabetes and associated hyperlipedaemia.
研究了管花肉苁蓉甲醇提取物在链脲佐菌素（STZ）诱导的糖尿病大鼠中的降血糖和降血脂作用。通过降低空腹血糖（第 4 周时降低 54%）和口服葡萄糖耐量试验 120 分钟时的血糖峰值来评估降血糖活性。此外，该提取物还使血浆胰岛素增加了 206.8%。与糖尿病大鼠相比，提取物的降血脂作用表现为总胆固醇、甘油三酯和 LDL-胆固醇水平分别显著降低 41.5%、36.7%和 49.1%。有趣的是，与糖尿病大鼠相比，该提取物使保护性脂质 HDL-胆固醇增加了 147.97%。目前的数据表明，管花肉苁蓉甲醇提取物对 STZ 诱导的糖尿病大鼠具有降血糖和降血脂作用，这可能需要进一步的研究，以用于糖尿病和相关高脂血症的治疗。
