University of California, San Diego, Department of Psychiatry 9116a, 3350 La Jolla Village Drive, San Diego, CA 92116, USA.
Trends Neurosci. 2011 Oct;34(10):504-14. doi: 10.1016/j.tins.2011.06.003. Epub 2011 Aug 20.
Memories are often classified as hippocampus dependent or independent, and sleep has been found to facilitate both, but in different ways. In this Opinion, we explore the optimal neural state for cellular and systems consolidation of hippocampus-dependent memories that benefit from sleep. We suggest that these two kinds of consolidation, which are ordinarily treated separately, overlap in time and jointly benefit from a period of reduced interference (during which no new memories are formed). Conditions that result in reduced interference include slow wave sleep (SWS), NMDA receptor antagonists, benzodiazepines, alcohol and acetylcholine antagonists. We hypothesize that the consolidation of hippocampal-dependent memories might not depend on SWS per se. Instead, the brain opportunistically consolidates previously encoded memories whenever the hippocampus is not otherwise occupied by the task of encoding new memories.
记忆通常被分为海马体依赖型和非依赖型，研究发现睡眠能够促进这两种记忆，但方式不同。在本观点中，我们探讨了有利于睡眠的海马体依赖型记忆的细胞和系统巩固的最佳神经状态。我们认为，这两种通常分开处理的巩固过程在时间上是重叠的，并共同受益于一段减少干扰的时期（在此期间不会形成新的记忆）。减少干扰的条件包括慢波睡眠（SWS）、NMDA 受体拮抗剂、苯二氮䓬类药物、酒精和乙酰胆碱拮抗剂。我们假设，海马体依赖型记忆的巩固可能并不依赖于 SWS 本身。相反，大脑会在海马体不忙于编码新记忆的情况下，伺机巩固之前编码的记忆。
