Department of Ophthalmology, First People's Hospital of Shanghai Affiliated to Shanghai Jiaotong University, Shanghai, China.
Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6377-83. doi: 10.1167/iovs.11-7477.
To evaluate macular thickness/volume in a Chinese population of primary school children using optical coherence tomography (OCT), and assess its association with age, sex, spherical equivalent refraction (SE), body mass index (BMI), and intraocular pressure (IOP).
Healthy Chinese children (n = 806) from six randomly selected primary schools in Chongming County, Shanghai, China, were enrolled. Comprehensive standardized ophthalmic examinations included visual acuity, cycloplegic refraction, IOP, and fast macular scans using Stratus OCT. Mean values for the nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas, foveal minimum thickness, and macular volume were calculated.
OCT data from right eyes with high-quality scans were evaluated in 720 children (89.3% of total participants; 46.5% boys). Macular thickness and volume were normally distributed. The mean foveal minimum thickness was 140.0 ± 12.3 μm. There were significant differences between the boys and the girls in mean foveal volume (P = 0.023) and sectoral macular thickness in all the quadrants of the inner ring (P < 0.001 and P = 0.001) and temporal outer quadrant (P = 0.009). SE refraction correlated positively with inner and outer macular thickness and total macular volume (P < 0.001) and negatively with central macular volume (P = 0.012). BMI correlated significantly only with outer macular thickness (r = 0.074, P = 0.048). No age- and IOP-related differences were found in the macular parameters.
OCT demonstrated that macular thickness/volume was normally distributed in this sample of Chinese children, with variations in sex and SE. The variables in macular thickness/volume should be considered when diagnosing and monitoring school-aged children with diseases that affect the macula.
使用光学相干断层扫描（OCT）评估中国小学生的黄斑厚度/体积，并评估其与年龄、性别、等效球镜（SE）、体重指数（BMI）和眼内压（IOP）的相关性。
从上海市崇明县六所随机选定的小学招募了 806 名健康的中国儿童。全面的标准化眼科检查包括视力、睫状肌麻痹验光、IOP 和 Stratus OCT 的快速黄斑扫描。计算了 9 个早期糖尿病视网膜病变研究（ETDRS）区域、黄斑最小厚度和黄斑体积的平均值。
对 720 名（占总参与者的 89.3%；46.5%为男性）右眼高质量扫描的 OCT 数据进行了评估。黄斑厚度和体积呈正态分布。黄斑最小厚度的平均中心值为 140.0±12.3μm。男孩和女孩之间的黄斑中心凹体积（P=0.023）和内环所有象限的扇形黄斑厚度（P<0.001 和 P=0.001）以及颞外象限（P=0.009）存在显著差异。SE 折射与内、外黄斑厚度和总黄斑体积呈正相关（P<0.001），与中心黄斑体积呈负相关（P=0.012）。仅 BMI 与外黄斑厚度显著相关（r=0.074，P=0.048）。在黄斑参数方面，未发现年龄和 IOP 相关的差异。
OCT 显示，该中国儿童样本中黄斑厚度/体积呈正态分布，存在性别和 SE 的差异。在诊断和监测影响黄斑的疾病的学龄儿童时，应考虑黄斑厚度/体积的这些变量。
