Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.
Cell Mol Life Sci. 2012 Feb;69(4):487-500. doi: 10.1007/s00018-011-0760-0. Epub 2011 Jul 9.
Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
白细胞介素 (IL)-1 是一种前炎性细胞因子，在先天免疫以及正常组织稳态中具有重要作用。有趣的是，最近的研究还表明，IL-1 在肌动蛋白细胞骨架和细胞连接的动态变化中发挥作用。例如，用 IL-1α 处理不同的上皮细胞通常会导致肌动蛋白网络和细胞连接的重构，从而导致连接解体。在这篇综述中，我们强调了一些新的有趣的发现，表明 IL-1 是精子发生过程中睾丸生精上皮重构事件的关键参与者。
