白细胞介素-1 的生物学：细胞骨架和细胞连接动力学调节的新观点。
The biology of interleukin-1: emerging concepts in the regulation of the actin cytoskeleton and cell junction dynamics.
机构信息
Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Cell Mol Life Sci. 2012 Feb;69(4):487-500. doi: 10.1007/s00018-011-0760-0. Epub 2011 Jul 9.
Abstract
Interleukin (IL)-1 is a proinflammatory cytokine with important roles in innate immunity, as well as in normal tissue homeostasis. Interestingly, recent studies have also shown IL-1 to function in the dynamics of the actin cytoskeleton and cell junctions. For example, treatment of different epithelia with IL-1α often results in the restructuring of the actin network and cell junctions, thereby leading to junction disassembly. In this review, we highlight new and interesting findings that show IL-1 to be a critical player of restructuring events in the seminiferous epithelium of the testis during spermatogenesis.
摘要
白细胞介素 (IL)-1 是一种前炎性细胞因子，在先天免疫以及正常组织稳态中具有重要作用。有趣的是，最近的研究还表明，IL-1 在肌动蛋白细胞骨架和细胞连接的动态变化中发挥作用。例如，用 IL-1α 处理不同的上皮细胞通常会导致肌动蛋白网络和细胞连接的重构，从而导致连接解体。在这篇综述中，我们强调了一些新的有趣的发现，表明 IL-1 是精子发生过程中睾丸生精上皮重构事件的关键参与者。
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