Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Egypt.
Int J Radiat Biol. 2011 Oct;87(10):1045-51. doi: 10.3109/09553002.2011.602378. Epub 2011 Aug 8.
To study the effect of aqueous propolis extract (AEP) against indomethacin (Indo)-induced gastric ulcers in irradiated and non-irradiated rats.
Animals were irradiated at different radiation dose levels before the induction of ulcers. AEP was injected orally 1 hour before induction of gastric ulcers and the effects compared with those of lansoprazole (Lanso), which was used as a reference anti-ulcerogenic drug.
Pretreatment of rats, either irradiated or non-irradiated, with AEP effectively protected against Indo-induced gastric ulceration. This was associated with a reduction in acid output and peptic activity and an increase in the secretion of mucin. The mucosal prostaglandin E(2) (PGE(2)) level was also increased. The levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) were suppressed to the same extent after treatment. Both propolis and Lanso were effective in reducing the number of gastric lesions as well as the plasma level of malondialdehyde (MDA).
These findings indicate that the gastroprotective effect of AEP could be of value in the management of excessive gastric damage induced by radiation exposure.
研究水芹蜂胶提取物（AEP）对吲哚美辛（Indo）诱导的放射和未放射大鼠胃溃疡的影响。
在诱导溃疡前，动物接受不同辐射剂量水平的照射。AEP 在诱导胃溃疡前 1 小时口服注射，并与兰索拉唑（Lanso）进行比较，后者被用作参考抗溃疡药物。
AEP 预处理放射和未放射大鼠可有效预防 Indo 诱导的胃溃疡。这与胃酸分泌和消化性活性降低以及粘蛋白分泌增加有关。黏膜前列腺素 E2（PGE2）水平也增加。TNF-α 和 IL-1β 的水平在治疗后同样受到抑制。蜂胶和 Lanso 都能有效减少胃损伤的数量和血浆丙二醛（MDA）水平。
这些发现表明，AEP 的胃保护作用可能对管理因辐射暴露引起的过度胃损伤有价值。
