Armstrong P, Watters J, Whitfield A
Department of Anaesthesia, Edinburgh University, Royal Infirmary Edinburgh.
Anaesthesia. 1990 Nov;45(11):935-7. doi: 10.1111/j.1365-2044.1990.tb14622.x.
Eighty unpremedicated patients undergoing day-case hand surgery under intravenous regional anaesthesia were randomly allocated to receive, in a double-blind study, either 40 ml 0.75% prilocaine hydrochloride, with 5 ml 8.4% sodium bicarbonate or 5 ml 0.9% saline. The alkalinised group had significantly less pain on injection (p = 0.0045), during surgery (p = 0.0074) and 5 minutes after the tourniquet was deflated (p = 0.0027). The time elapsed between insertion of the block and commencement of surgery was not affected.
80例未接受术前用药、在静脉区域麻醉下接受日间手部手术的患者，在一项双盲研究中被随机分配，分别接受40毫升0.75%盐酸丙胺卡因加5毫升8.4%碳酸氢钠或5毫升0.9%生理盐水。碱化组在注射时（p = 0.0045）、手术期间（p = 0.0074）和止血带放气后5分钟（p = 0.0027）疼痛明显减轻。阻滞插入与手术开始之间的时间不受影响。
