Lu Xiuli, Wang Jing, Cao Xiangyu, Li Mingxin, Xiao Chunling, Yasui Takahiro, Gao Bing
School of Life Sciences, Liaoning University, Shenyang, China.
Urol Ann. 2011 May;3(2):71-4. doi: 10.4103/0974-7796.82171.
Melamine was known as a new risk for kidney stone due to recent incidences of milk powder contamination in China. Here, we performed a retrospective study to investigate whether age, gender, and urinary pH affect melamine-associated kidney stone risk.
A retrospective review was performed of 217 children aged less than 3 years old. All children had a history of being fed with Sanlu milk powder contaminated by melamine, and underwent a clinical screening on kidney stone in Shenyang from November 2008 to February 2009. A comparison with the Chi-square was conducted between 83 cases and 125 normal subjects. The difference between children's gender, age, and urinary pH was evaluated.
A total of 208 subjects, 136 boys and 72 girls, were included in the study. Significant association was observed between melamine-associated kidney stone risk and gender [odds ratio (OR), 2.03; 95% confidence interval (CI), 1.11-3.74; P=0.02] and urinary pH (OR, 1.78; 95% CI, 1.01-3.11; P=0.04), respectively. Male children were at about twofold increased melamine-associated kidney stone risk compared with female children. Acidic urine showed about 1.78-fold increased melamine-associated kidney stone risk compared with normal urine.
Our investigation results showed an association of gender and urinary pH with melamine-associated kidney stone formation risk.
由于近期中国发生的奶粉污染事件，三聚氰胺被认为是肾结石的一种新风险因素。在此，我们进行了一项回顾性研究，以调查年龄、性别和尿液pH值是否会影响与三聚氰胺相关的肾结石风险。
对217名3岁以下儿童进行了回顾性研究。所有儿童均有食用受三聚氰胺污染的三鹿奶粉的历史，并于2008年11月至2009年2月在沈阳接受了肾结石临床筛查。对83例病例和125名正常受试者进行了卡方检验比较。评估了儿童性别、年龄和尿液pH值之间的差异。
共有208名受试者纳入研究，其中男孩136名，女孩72名。观察到与三聚氰胺相关的肾结石风险分别与性别[比值比（OR），2.03；95%置信区间（CI），1.11 - 3.74；P = 0.02]和尿液pH值（OR，1.78；95% CI，1.01 - 3.11；P = 0.04）存在显著关联。与女童相比，男童患与三聚氰胺相关肾结石的风险约增加两倍。酸性尿液与正常尿液相比，患与三聚氰胺相关肾结石的风险约增加1.78倍。
我们的调查结果显示性别和尿液pH值与与三聚氰胺相关的肾结石形成风险有关。
