未接种流感疫苗人群中流感 A 病毒抗体的血清学调查。
Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination.
机构信息
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, China.
出版信息
Clin Microbiol Infect. 2011 Sep;17(9):1347-9. doi: 10.1111/j.1469-0691.2011.03538.x. Epub 2011 Jul 13.
Abstract
A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought.
摘要
在中国，我们对一组没有流感疫苗接种史的人群进行了血清抗体流感病毒检测。采用血凝抑制（HI）试验，我们发现季节性 H3N2 的血清阳性率明显高于季节性 H1N1。大流行（H1N1）2009 病毒抗体阳性样本在疫情爆发后 1 年从 0.6%上升到 4.5%（p<0.01）。有趣的是，HI 和中和试验显示，该人群中有 1.4%的人具有识别 H9N2 禽流感病毒的抗体，这表明感染这种亚型可能比之前认为的更为常见。
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