一种来自放线菌链霉菌（菌株172614）的新型星形孢菌素类似物。

A new staurosporine analog from Actinomycetes Streptomyces sp. (172614).

作者信息

Li Xiao-Bin, Tang Jin-Shan, Gao Hao, Ding Rong, Li Jia, Hong Kui, Yao Xin-Sheng

机构信息

College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.

出版信息

J Asian Nat Prod Res. 2011 Aug;13(8):765-9. doi: 10.1080/10286020.2011.586342.

DOI:10.1080/10286020.2011.586342

PMID:21751847

Abstract

A new staurosporine analog, 10'-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

摘要

一种新的星形孢菌素类似物，10'-{5″-[(甲氧基羰基)氨基]-2″-甲基}-苯基氨基羰基星形孢菌素(1)，与星形孢菌素(2)一起，从链霉菌属放线菌(172614)的培养液中获得。通过包括紫外、质谱、核磁共振和圆二色谱在内的综合光谱分析阐明了它们的结构。药理实验表明，1和2对人结肠肿瘤细胞HCT-116显示出显著的细胞毒性。