海绵源链霉菌 sp. Sp080513GE-26 中的四环喹诺辛和 5-亚氨基阿糖菌素

Tetracenoquinocin and 5-iminoaranciamycin from a sponge-derived Streptomyces sp. Sp080513GE-26.

机构信息

Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.

出版信息

J Nat Prod. 2010 Apr 23;73(4):755-8. doi: 10.1021/np9007409.

DOI:10.1021/np9007409

PMID:20192240

Abstract

Two new anthracyclines, tetracenoquinocin (1) and 5-iminoaranciamycin (2), together with the known compounds aranciamycin (3) and antibiotic SM 173B were isolated from the culture of Streptomyces sp. Sp080513GE-26 associated with a marine sponge, Haliclona sp. The structures of 1 and 2 were established on the basis of extensive NMR and MS analyses along with (13)C-labeling experiments. The compounds 1-3 were evaluated for cytotoxicity against two cancer cell lines.

摘要

从一株与海洋海绵 Haliclona sp. 共生的链霉菌 Sp080513GE-26 的发酵液中分离得到了两个新的蒽环类抗生素tetracenoquinocin (1) 和 5-iminoaranciamycin (2)，以及已知化合物 aranciamycin (3) 和抗生素 SM 173B。通过大量的 NMR 和 MS 分析以及 13C 标记实验，确定了化合物 1 和 2 的结构。对化合物 1-3 进行了两种癌细胞系的细胞毒性评价。