局部病毒感染期间的全身反应：I 型干扰素拉响警报。
Systemic responses during local viral infections: type I IFNs sound the alarm.
机构信息
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Curr Opin Immunol. 2011 Aug;23(4):495-9. doi: 10.1016/j.coi.2011.06.003. Epub 2011 Jul 13.
Abstract
Type I IFNs are well known for their role in controlling virus replication and spread. Type I IFNs produced by the infected tissue also signal beyond the boundaries of the infection to regulate different elements of the anti-viral immune response. Recent reports show that type I IFNs directly condition naive monocytes residing in the distal bone marrow (BM) and induce the expression of effector molecules in memory T cells, before their recruitment to the infected site. In addition, hematopoietic stem cells (HSCs) were shown to enter the cell cycle in response to systemically distributed type I IFNs. These discoveries expand our understanding of the pleiotropic effects of type I IFNs during infection and highlight the critical role of systemic signals in the development of an effective response to a localized viral infection.
摘要
I 型干扰素在控制病毒复制和传播方面的作用是众所周知的。受感染组织产生的 I 型干扰素也会在感染范围之外发出信号，调节抗病毒免疫反应的不同元件。最近的报告显示，I 型干扰素直接调节位于远端骨髓（BM）中的幼稚单核细胞，并在其募集到感染部位之前诱导记忆 T 细胞中效应分子的表达。此外，造血干细胞（HSCs）被证明会对系统性分布的 I 型干扰素做出反应而进入细胞周期。这些发现扩展了我们对感染期间 I 型干扰素多效性作用的理解，并强调了系统性信号在局部病毒感染的有效反应发展中的关键作用。
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