Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Annu Rev Biomed Eng. 2011 Aug 15;13:185-217. doi: 10.1146/annurev-bioeng-071910-124703.
Small multicellular model organisms such as the invertebrate nematode C. elegans and the vertebrate zebrafish provide unique opportunities for both basic science and pharmaceutical discovery. In recent years, there have been significant breakthroughs in technologies to manipulate and image these organisms for a variety of purposes ranging from behavioral studies of neuronal circuits to high-throughput screening. Here, we review these advancements with a particular focus on the optically transparent model organisms C. elegans and zebrafish.
小型多细胞模式生物，如无脊椎动物秀丽隐杆线虫和脊椎动物斑马鱼，为基础科学和药物发现提供了独特的机会。近年来，在操纵和成像这些生物体的技术方面取得了重大突破，这些生物体的用途从神经元回路的行为研究到高通量筛选不等。在这里，我们特别关注透明的模式生物秀丽隐杆线虫和斑马鱼，综述了这些进展。
