Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Am J Clin Pathol. 2011 Aug;136(2):168-82. doi: 10.1309/AJCPENJ68FFBRIYB.
Session 1 of the 2009 Workshop of the Society for Hematopathology/European Association of Haematopathology, Cleveland, OH, focused on plasma cell neoplasms. This report summarizes the salient diagnostic, clinical, and genetic features of plasma cell myeloma (PCM) and related neoplasms. Based on the cases submitted to the workshop, we highlight common diagnostic issues and unusual manifestations of plasma cell neoplasms, such as t(11;14)+ PCM, plasma cell leukemia, and nonsecretory plasmacytoma, as well as plasmablastic transformation of PCM. Additional issues repeatedly raised at the workshop included the differential diagnosis of extramedullary dissemination of PCM vs primary extramedullary plasmacytoma and plasmablastic lymphoma; systemic plasma cell neoplasms in immunocompromised people; and Epstein-Barr virus-associated plasma cell neoplasms. Difficult cases with borderline features presented by submitters emphasized the necessity of integrating clinical, immunophenotypic, and genetic features for appropriate classification of these disorders.
第 2009 届血液病理学协会/欧洲血液病理学协会研讨会第 1 场，聚焦于浆细胞肿瘤。本报告总结了浆细胞骨髓瘤（PCM）及相关肿瘤的主要诊断、临床和遗传特征。基于提交给研讨会的病例，我们强调了浆细胞肿瘤的常见诊断问题和不典型表现，如 t（11；14）+ PCM、浆细胞白血病和无分泌性浆细胞瘤，以及 PCM 的浆母细胞转化。在研讨会上反复提出的其他问题包括 PCM 的髓外播散与原发性髓外浆细胞瘤和浆母细胞淋巴瘤的鉴别诊断；免疫功能低下人群中的全身性浆细胞肿瘤；以及 EBV 相关浆细胞肿瘤。提交者提供的具有边界特征的疑难病例强调了为这些疾病进行适当分类时，整合临床、免疫表型和遗传特征的必要性。
