Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaussstrasse 17, 38106 Braunschweig, Germany.
Appl Microbiol Biotechnol. 2011 Sep;91(5):1287-96. doi: 10.1007/s00253-011-3457-2. Epub 2011 Jul 15.
In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.
在生物经济兴起的时代，五碳化合物 1,5-二氨基戊烷作为平台化学品受到越来越多的关注，特别是作为生物基聚合物的创新构建块。对生物基供应 1,5-二氨基戊烷的巨大兴趣强烈刺激了用于工程化生产菌株的研究。基于与微生物 1,5-二氨基戊烷代谢相关的途径和反应的最新知识，该综述涵盖了新型系统代谢工程方法，用于构建谷氨酸棒杆菌或大肠杆菌的超高产细胞工厂。这与从可再生原料通过 1,5-二氨基戊烷到涉及生物工艺工程考虑因素以实现经济供应的创新生物聚合物的整个价值链相结合。
