Finnish Food Safety Authority, Risk Assessment Unit, Helsinki, Finland.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Nov;28(11):1483-91. doi: 10.1080/19440049.2011.593559. Epub 2011 Jul 18.
A deterministic exposure assessment using the Nusser method that adjusts for within-subject variation and for nuisance effects among Finnish children and adults was carried out. The food consumption data covered 2038 adults (25-74 years old) and 1514 children of 1, 3 and 6 years of age, with the data on foods' acrylamide content obtained from published Finnish studies. We found that acrylamide exposure was highest among the 3-year-old children (median = 1.01 µg kg(-1) bw day(-1), 97.5th percentile = 1.95 µg kg(-1) bw day(-1)) and lowest among 65-74-year-old women (median = 0.31 µg kg(-1) bw day(-1), 97.5th percentile = 0.69 µg kg(-1) bw day(-1)). Among adults, the most important source of acrylamide exposure was coffee, followed by casseroles rich in starch, then rye bread. Among children, the most important sources were casseroles rich in starch and then biscuits and, finally, chips and other fried potatoes. Replacing lightly roasted coffee with dark-roasted, swapping sweet wheat buns for biscuits, and decreasing the acrylamide content of starch-based casseroles and rye bread by 50% would result in a 50% decrease in acrylamide exposure in adults. Among children, substituting boiled potatoes for chips and other friend potatoes and replacing biscuits with sweet wheat buns while lowering the acrylamide content of starch-based casseroles by 50% would lead to acrylamide exposure that is only half of the original exposure. In conclusions, dietary modifications could have a large impact in decreasing acrylamide exposure.
采用 Nusser 方法进行了确定性暴露评估,该方法调整了个体内变异和芬兰儿童和成人中混杂效应。食物消费数据涵盖了 2038 名成年人(25-74 岁)和 1514 名 1 岁、3 岁和 6 岁的儿童,食物中丙烯酰胺含量的数据来自已发表的芬兰研究。我们发现,3 岁儿童的丙烯酰胺暴露量最高(中位数=1.01μgkg(-1)bwday(-1),97.5 百分位=1.95μgkg(-1)bwday(-1)),65-74 岁女性最低(中位数=0.31μgkg(-1)bwday(-1),97.5 百分位=0.69μgkg(-1)bwday(-1))。在成年人中,丙烯酰胺暴露的最重要来源是咖啡,其次是富含淀粉的砂锅菜,然后是黑麦面包。在儿童中,最重要的来源是富含淀粉的砂锅菜,然后是饼干,最后是薯条和其他炸土豆。将轻度烘焙的咖啡换成深度烘焙的咖啡,将甜麦面包换成饼干,并将淀粉类砂锅菜和黑麦面包的丙烯酰胺含量降低 50%,可使成年人的丙烯酰胺暴露量降低 50%。在儿童中,用煮土豆代替薯条和其他炸土豆,用甜麦面包代替饼干,同时将淀粉类砂锅菜的丙烯酰胺含量降低 50%,则丙烯酰胺暴露量仅为原来的一半。总之,饮食的改变可以大大降低丙烯酰胺的暴露量。