Kandasamy Mahesh, Reilmann Ralf, Winkler Jürgen, Bogdahn Ulrich, Aigner Ludwig
Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria.
Neurol Res Int. 2011;2011:124256. doi: 10.1155/2011/124256. Epub 2011 May 19.
The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.
神经干细胞龛具有在成人大脑中产生新的功能性神经元的再生能力，这表明在损伤或疾病后内源性神经元替代的可能性。亨廷顿舞蹈病（HD）是一种神经退行性疾病，其特征是基底神经节中的神经元丢失，导致运动、认知和心理障碍。显然，为了将神经干细胞龛作为HD修复策略的治疗理念，了解在这种神经退行性条件下神经干细胞龛的细胞和分子组成非常重要。本文主要讨论了目前关于成人大脑海马神经干细胞龛调节的知识，以及在HD情况下它可能受到损害的机制。
