在日本血友病患者中频繁检测到丙型肝炎病毒美国毒株。
Frequent detection of hepatitis C virus US strain in Japanese hemophiliacs.
作者信息
Hijikata M, Kato N, Mori S, Ootsuyama Y, Nakagawa M, Sugimura T, Ohkoshi S, Kojima H, Meguro T, Taki M
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1990 Dec;81(12):1195-7. doi: 10.1111/j.1349-7006.1990.tb02676.x.
Abstract
Hemophiliacs have been found to be at high risk of hepatitis. Hemophiliacs in Japan receive imported clotting factors as well as domestic ones. Recently we found that hepatitis C virus (HCV) could be classified into at least two types, HCV-US and HCV-J, depending on the nucleotide sequence. We analyzed the nucleotide sequences of virus RNAs from the plasma of patients with hemophilia A or B and found HCV-US in 3 of 4 Japanese hemophiliacs examined.
摘要
已发现血友病患者感染肝炎的风险很高。日本的血友病患者既接受进口凝血因子，也接受国产凝血因子。最近我们发现，根据核苷酸序列，丙型肝炎病毒（HCV）可至少分为两种类型，即HCV-US和HCV-J。我们分析了甲型或乙型血友病患者血浆中病毒RNA的核苷酸序列，在所检测的4名日本血友病患者中，有3名发现了HCV-US。
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