儿童肥胖中基质金属蛋白酶2（MMP2）启动子多态性的分析
Analysis of MMP2 promoter polymorphisms in childhood obesity.
作者信息
Morgan Angharad R, Han Dug Yeo, Thompson John Md, Mitchell Edwin A, Ferguson Lynnette R
机构信息
Discipline of Nutrition, FMHS, The University of Auckland, New Zealand.
出版信息
BMC Res Notes. 2011 Jul 21;4:253. doi: 10.1186/1756-0500-4-253.
BACKGROUND
Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.
FINDINGS
546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.
CONCLUSION
We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.
背景
多项证据表明基质金属蛋白酶-2（MMP-2）在肥胖中可能具有功能性作用。本研究的目的是评估MMP-2启动子多态性在新西兰人群中作为儿童肥胖指标的体脂百分比（PBF）中的作用。
研究结果
使用Sequenom基因分型平台对奥克兰出生体重协作研究（ABC）的546份样本进行了三种MMP-2启动子单核苷酸多态性-1306 C/T（rs243865）、-1575G/A（rs243866）和-790 T/G（rs243864） 的基因分型。结果表明，一种MMP-2启动子单倍型与新西兰7岁儿童的PBF相关。
结论
我们之前已确定环境因素与该研究组中PBF的差异相关，现在我们证明了可能存在的遗传因素。
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